Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).
Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).
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Galectin-3 作为疾病诊断的新型生物标志物和治疗靶点
DOI：
10.3892/ijmm.2017.3311
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发表时间：
2018-03
影响因子：
5.4
通讯作者：
Yuan H
中科院分区：
文献类型：
--
作者：
Dong R;Zhang M;Hu Q;Zheng S;Soh A;Zheng Y;Yuan H
Galectin-3是半乳糖凝集素家族的一员，是一种β-半乳糖苷结合凝集素，具有≥1个进化保守的糖识别结构域。它以碳水化合物依赖性和非依赖性方式结合蛋白质。半乳糖凝集素-3主要位于细胞质中;然而，它穿梭进入细胞核并分泌到细胞表面上和生物流体（包括血清和尿液）中。它在许多生物学活动中发挥重要作用，包括细胞生长、凋亡、前mRNA剪接、分化、转化、血管生成、炎症、纤维化和宿主防御。许多先前的研究表明，半乳糖凝集素-3可用作某些类型的心脏病，肾病和癌症的诊断或预后生物标志物。随着越来越多的证据支持galectin-3的功能和应用，目前的审查旨在总结最新的文献，生物标志物的特点和潜在的治疗应用galectin-3在相关疾病。
Galectin-3 is a member of the galectin family, which are β-galactoside-binding lectins with ≥1 evolutionary conserved carbohydrate-recognition domain. It binds proteins in a carbohydrate-dependent and -independent manner. Galectin-3 is predominantly located in the cytoplasm; however, it shuttles into the nucleus and is secreted onto the cell surface and into biological fluids including serum and urine. It serves important functions in numerous biological activities including cell growth, apoptosis, pre-mRNA splicing, differentiation, transformation, angiogenesis, inflammation, fibrosis and host defense. Numerous previous studies have indicated that galectin-3 may be used as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease and cancer. With emerging evidence to support the function and application of galectin-3, the current review aims to summarize the latest literature regarding the biomarker characteristics and potential therapeutic application of galectin-3 in associated diseases.
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影响因子：
3.6
作者：
Chang YY;Chen A;Wu XM;Hsu TP;Liu LY;Chen YH;Wu YW;Lin HJ;Hsu RB;Lee CM;Wang SS;Lo MT;Chen MF;Lin YH
通讯作者：
Lin YH
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通讯作者：
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作者：
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通讯作者：
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