Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer.
Overexpressed CMTM6 Improves Prognosis and Associated With Immune Infiltrates of Ovarian Cancer.
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过度表达的 CMTM6 可改善预后并与卵巢癌的免疫浸润相关。
DOI：
10.3389/fmolb.2022.769032
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发表时间：
2022
影响因子：
5
通讯作者：
Han L
中科院分区：
文献类型：
--
作者：
Yin B;Ding J;Hu H;Yang M;Huang B;Dong W;Li F;Han L
卵巢癌（ovarian cancer，OV）是一种上皮性恶性肿瘤，其高死亡率和缺乏有效的治疗手段一直困扰着人们。趋化因子样因子（CKLF）样MARVEL跨膜结构域6（CMTM6）可在多种癌症中观察到，但其在OV中的作用尚不清楚。因此，CMTM6在OV中的预后价值和潜在机制进行了初步评估。在这里，我们确定CMTM6表达高于正常对照。然而，CMTM6的上调与更好的预后相关。GSEA结果表明，CMTM6参与免疫相关和代谢相关途径。对CMTM6共表达基因进行GO/KEGG分析，以调查CMTM6在OV中可能的调控作用。随后，CMTM6表达与免疫细胞浸润水平和多种免疫细胞标志物集的表达呈正相关。重要的是，CMTM6可能部分通过调节OV中的免疫浸润来影响预后。最后，拷贝数变异（CNVs）和DNA甲基化可能促使OV中CMTM6的异常表达。总之，CMTM6可以作为OV患者的新的预后生物标志物。
Ovarian cancer (OV) is an epithelial malignancy that intrigues people for its high mortality and lack of efficient treatment. Chemokine-like factor (CKLF)–like MARVEL transmembrane domain containing 6 (CMTM6) can be observed in various cancers, but its part in OV remains little known. Hence, the prognostic value and underlying mechanism of CMTM6 in OV were preliminarily evaluated. Here, we determined that CMTM6 expression was higher than that in normal controls. However, the upregulation of CMTM6 was associated with better prognosis. GSEA results suggested that CMTM6 is involved in the immune-related and metabolism-related pathways. GO/KEGG analysis of CMTM6 coexpressed genes was performed to survey the possible regulatory roles of CMTM6 in OV. Subsequently, CMTM6 expression was positively correlated with the infiltration levels of immune cells and the expression of diverse immune cell marker sets. Importantly, CMTM6 may influence prognosis partially by regulating immune infiltration in OV. Last, copy number variations (CNVs) and DNA methylation might prompt the abnormal CMTM6 expression in OV. In conclusion, CMTM6 can serve as a novel prognostic biomarker in patients with OV.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
4.1
作者：
Han, WL;Lou, YX;Ma, DL
通讯作者：
Ma, DL
Th17诱导自体树突状细胞疫苗接种可促进卵巢癌患者的抗原特异性细胞和体液免疫。
影响因子：
16.6
作者：
Block MS;Dietz AB;Gustafson MP;Kalli KR;Erskine CL;Youssef B;Vijay GV;Allred JB;Pavelko KD;Strausbauch MA;Lin Y;Grudem ME;Jatoi A;Klampe CM;Wahner-Hendrickson AE;Weroha SJ;Glaser GE;Kumar A;Langstraat CL;Solseth ML;Deeds MC;Knutson KL;Cannon MJ
通讯作者：
Cannon MJ
DOI：
10.1007/s00262-020-02691-9
发表时间：
2021-03
期刊：
Cancer immunology, immunotherapy : CII
影响因子：
--
作者：
Liu LL;Zhang SW;Chao X;Wang CH;Yang X;Zhang XK;Wen YL;Yun JP;Luo RZ
通讯作者：
Luo RZ
影响因子：
64.5
作者：
Liu J;Lichtenberg T;Hoadley KA;Poisson LM;Lazar AJ;Cherniack AD;Kovatich AJ;Benz CC;Levine DA;Lee AV;Omberg L;Wolf DM;Shriver CD;Thorsson V;Cancer Genome Atlas Research Network;Hu H
通讯作者：
Hu H