The translational neuroscience of sleep: A contextual framework.

The translational neuroscience of sleep: A contextual framework.
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睡眠的转化神经科学:语境框架。

DOI:
10.1126/science.abj8188
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发表时间:
2021-10-29
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Fernandez FX
Fernandez FX
中科院分区:
其他
文献类型:
--
作者:
Grandner MA;Fernandez FX

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睡眠与大脑和周围的许多生理过程交织在一起,因此对我们的健康产生了巨大的影响。然而,睡眠存在于社会环境背景中。将睡眠健康的决定因素——从个人到社会层面的因素——置于环境中,将使神经科学家能够更有效地将睡眠健康转化为临床实践。关键的挑战和机遇涉及(i)认识和探索睡眠的功能作用,(ii)阐明与关键结果相关的因果机制,(iii)开发更丰富的模型系统,(iv)将模型与已知的背景因素联系起来,以及(v)利用多感官技术的进步。迎接这些挑战和机遇将有助于超越学科界限,这样与睡眠相关的社会环境考虑将成为临床中越来越多的存在。
Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental context. Contextualizing sleep health with respect to its determinants—from individual- to societal-level factors—would enable neuroscientists to more effectively translate sleep health into clinical practice. Key challenges and opportunities pertain to (i) recognizing and exploring sleep’s functional roles, (ii) clarifying causal mechanisms in relation to key outcomes, (iii) developing richer model systems, (iv) linking models to known contextual factors, and (v) leveraging advances in multisensory technology. Meeting these challenges and opportunities would help transcend disciplinary boundaries such that social-environmental considerations related to sleep would become an ever-greater presence in the clinic.
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发表时间: 2022-03
影响因子: 3.1
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