AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder.
AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder.
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DOI：
10.1016/j.jad.2011.10.001
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发表时间：
2012-02
影响因子：
6.6
通讯作者：
Dean, Brian
中科院分区：
文献类型：
--
作者：
Gibbons, Andrew Stuart;Brooks, Lucy;Scarr, Elizabeth;Dean, Brian
谷氨酸被认为与抑郁症和双相情感障碍的病理生理学有关；然而，谷氨酸能异常信号的分子变化仍然知之甚少。虽然之前的研究表明NMDA受体可能参与了情绪障碍的病理生理学，但目前还不清楚非NMDA受体是否也参与其中。因此，我们试图检测非NMDA、离子型谷氨酸受体、AMPA受体和海人藻酸受体在情绪障碍中的表达是否发生了变化。用[~3H]AMPA和[~H]Kainate分别测定了10例抑郁症患者、10例双相情感障碍患者和10例对照患者死后中枢前扣带回(BA24)和背外侧前额叶皮质(BA46)内AMPA和海人藻酸受体的水平。与对照组相比，重度抑郁障碍组BA24(p<；0.05)的[~3H]AMPA结合密度增加20.7%~27.7%，而BA46(p>；0.05)无明显变化。与对照组相比，双相情感障碍患者BA24或BA46的AMPA结合密度均无改变(p>；0.05)。与对照组相比，BA24或BA46的海人藻酸结合力均未发生改变(p>；0.05)。本研究采用小样本量(n=10)。受试者并不是吸毒的天真。我们的数据表明，扣带回前部AMPA受体水平的升高与抑郁症的病理生理学有关。这一数据对针对AMPA受体的新型抗抑郁药物的开发具有重要意义。
Glutamate is thought to be involved in the pathophysiology of major depressive disorder and bipolar disorder; however, the molecular changes underlying abnormal glutamatergic signalling remain poorly understood. While previous studies have suggested that the NMDA receptor may be involved in the pathophysiology of mood disorders, it is unclear whether the non-NMDA receptors are also involved. Therefore, we sought to examine whether the expression of the non-NMDA, ionotropic glutamate receptors, AMPA receptor and kainate receptor, is altered in mood disorders. We used [3H]AMPA and [3H]kainate to measure the levels of AMPA and kainate receptor, respectively, in the anterior cingulate (BA 24) and dorsolateral prefrontal cortex (BA 46) from post-mortem CNS in 10 subjects with major depressive disorder, 10 subjects with bipolar disorder and 10 control subjects. A 20.7% to 27.7% increase in [3H]AMPA binding density was seen in BA 24 (p < 0.05) but not BA 46 (p > 0.05) in major depressive disorder compared to control levels. [3H]AMPA binding density was not changed in bipolar disorder in either BA 24 or BA 46 (p > 0.05) compared to controls. [3H]Kainate binding was not changed in either BA 24 or BA 46 in either disorder compared to controls (p > 0.05). Small sample sizes (n = 10) were used in this study. The subjects were not drug naïve. Our data suggests increased in AMPA receptor levels in the anterior cingulate are involved in the pathophysiology of major depressive disorder. This data has relevance for the development of new anti-depressant drugs targeted towards the AMPA receptors.
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影响因子：
5.4
作者：
Scarr, E;Pavey, G;Dean, B
通讯作者：
Dean, B
影响因子：
6.6
作者：
Dean, B;Pavey, G;Copolov, D
通讯作者：
Copolov, D
影响因子：
4.7
作者：
Jouhanneau, Jean-Sebastien;Ball, Simon M.;Isaac, John T. R.
通讯作者：
Isaac, John T. R.
影响因子：
4.7
作者：
Li, X;Tizzano, JP;Skolnick, P
通讯作者：
Skolnick, P
DOI：
10.1016/0169-328x(94)00219-5
发表时间：
1995-02-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
KINGSBURY, AE;FOSTER, OJF;MARSDEN, CD
通讯作者：
MARSDEN, CD