Serum midkine levels are increased in patients with various types of carcinomas.
Serum midkine levels are increased in patients with various types of carcinomas.
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DOI：
10.1054/bjoc.2000.1339
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发表时间：
2000-09
影响因子：
8.8
通讯作者：
Muramatsu, T
中科院分区：
文献类型：
--
作者：
Ikematsu, S;Yano, A;Aridome, K;Kikuchi, M;Kumai, H;Nagano, H;Okamoto, K;Oda, M;Sakuma, S;Aikou, T;Muramatsu, H;Kadomatsu, K;Muramatsu, T
中期因子(MK)是一种与肝素结合的生长因子，在许多类型的人类癌症中表达水平升高。用兔、鸡抗体建立的双抗体夹心酶联免疫分析法检测正常对照血清MK水平为0.154±0.076(平均值±SD)ng·ml~(-1)，其临界值为0.5ngml~(-1)。癌症患者血清MK水平显著升高(P<0.001)，87%的患者血清MK水平大于0.5ngml~(-1)。炎症标志物C反应蛋白水平与血清MK水平之间无相关性或相关性较弱。此外，在胃癌和肺癌的病例中，I期癌症患者已经显示出血清MK水平升高。提示血清MK可作为一种通用的肿瘤标志物，具有良好的临床应用前景。©2000癌症研究活动
The level of expression of midkine (MK), a heparin-binding growth factor, is increased in many types of human carcinomas. An enzyme-linked immunoassay, which utilizes a combination of rabbit and chicken antibodies revealed that serum MK level in the controls (n= 135) was 0.154 ± 0.076 (mean ± SD) ng ml–1with an apparent cut-off value as 0.5 ng ml–1. Serum MK level was significantly elevated in the cancer patients (n= 150) (P< 0.001); 87% of the patients showed levels of more than 0.5 ng ml–1. All ten types of cancer examined showed a similar profile of serum MK level. There was no or weak correlation between C-reactive protein level, a marker of inflammation, and serum MK level. Furthermore, in case of gastric carcinoma and lung carcinoma, patients with stage I carcinoma already showed elevated serum MK levels. The present results indicated that serum MK could serve as a general tumour marker with a good potential for clinical application. © 2000 Cancer Research Campaign
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影响因子：
4.2
作者：
MICHIKAWA, M;KIKUCHI, S;KIM, SU
通讯作者：
KIM, SU
影响因子：
2.7
作者：
Qi, MS;Ikematsu, S;Kadomatsu, K
通讯作者：
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影响因子：
8.8
作者：
Ye, C;Qi, M;Kadomatsu, K
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Kadomatsu, K
影响因子：
15.9
作者：
Horiba, M;Kadomatsu, K;Muramatsu, T
通讯作者：
Muramatsu, T
DOI：
10.1016/0006-291x(91)91475-r
发表时间：
1991-01-31
影响因子：
3.1
作者：
RAULAIS, D;LAGENTECHEVALLIER, O;VIGNY, M
通讯作者：
VIGNY, M