Curvature of double-membrane organelles generated by changes in membrane size and composition.
Curvature of double-membrane organelles generated by changes in membrane size and composition.
复制标题
DOI：
10.1371/journal.pone.0032753
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lipowsky R
中科院分区：
文献类型：
--
作者：
Knorr RL;Dimova R;Lipowsky R
瞬时双膜细胞器是细胞过程中的关键参与者，如自噬，繁殖和病毒感染。这些细胞器是由弯曲和关闭的平面，双膜片。蛋白质被认为是重要的，在这些形态的转变，但弯曲产生的基本机制知之甚少。在这里，我们描述了一种新的机制，这种曲率的产生主要取决于三个膜的性能：双膜片的横向尺寸，其高度弯曲的轮辋的分子组成，以及可能的不对称性的两个平面之间的片材。这种机制在进化上是有利的，因为它不需要主动过程，并且即使在细胞内的资源受到限制（如在饥饿期间）时也容易获得，这可以诱导自噬和孢子形成。我们确定的曲率生成，细胞器的大小，弯曲方向和形态的蛋白质辅助调节的途径。我们的理论还提供了一个机制，在内质网和高尔基池中发现的大型双膜片状结构的稳定。
Transient double-membrane organelles are key players in cellular processes such as autophagy, reproduction, and viral infection. These organelles are formed by the bending and closure of flat, double-membrane sheets. Proteins are believed to be important in these morphological transitions but the underlying mechanism of curvature generation is poorly understood. Here, we describe a novel mechanism for this curvature generation which depends primarily on three membrane properties: the lateral size of the double-membrane sheets, the molecular composition of their highly curved rims, and a possible asymmetry between the two flat faces of the sheets. This mechanism is evolutionary advantageous since it does not require active processes and is readily available even when resources within the cell are restricted as during starvation, which can induce autophagy and sporulation. We identify pathways for protein-assisted regulation of curvature generation, organelle size, direction of bending, and morphology. Our theory also provides a mechanism for the stabilization of large double-membrane sheet-like structures found in the endoplasmic reticulum and in the Golgi cisternae.
登录
查看更多内容
DOI：
10.1038/nrmicro1890
发表时间：
2008-05
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Miller S;Krijnse-Locker J
通讯作者：
Krijnse-Locker J
DOI：
10.1083/jcb.200711112
发表时间：
2008-07-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Geng J;Baba M;Nair U;Klionsky DJ
通讯作者：
Klionsky DJ
影响因子：
21.3
作者：
Hayashi-Nishino, Mitsuko;Fujita, Naonobu;Yamamoto, Akitsugu
通讯作者：
Yamamoto, Akitsugu
影响因子：
4.5
作者：
Köchl, R;Hu, XW;Tooze, SA
通讯作者：
Tooze, SA
影响因子：
7.8
作者：
Ladinsky, M S;Mastronarde, D N;McIntosh, J R;Howell, K E;Staehelin, L A
通讯作者：
Staehelin, L A