Lead Exposure and Conventional and Ambulatory Blood Pressure: A Prospective Population Study
Lead Exposure and Conventional and Ambulatory Blood Pressure: A Prospective Population Study
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铅暴露与常规血压和动态血压：一项前瞻性人群研究
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
D. Wildemeersch
中科院分区：
文献类型：
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作者：
J. Staessen;H. Roels;R. Fagard;A. Amery;L. Bieniaszewski;C. Bulpitt;H. Celis;P. Dolenc;P. Lijnen;V. Petrov;L. Thijs;A. Bernard;J. Buchet;R. Lauwerys;F. Dondeyne;D. Wildemeersch
Objective. - 以前瞻性方式评估低水平铅暴露与血压之间的关联。设计- 前瞻性队列研究。设置. - 一般人参与者-1985年至1989年在比利时对随机人口抽样（N=728; 49%为男性;年龄范围为20-82岁）进行了研究，并于1991年至1995年进行了重新审查。平均结果测量。- 在基线和随访时，通过常规血压计（共15次读数）测量血压，并在随访时通过24小时动态监测测量血压。铅暴露估计从血铅和锌原卟啉浓度。多变量分析控制了性别、年龄、体重指数、吸烟和饮酒习惯、体力活动、工作暴露、社会阶层、绝经状态、药物使用（抗高血压药物、口服避孕药、激素替代治疗）、红细胞压积或血红蛋白、血清总钙浓度、24小时尿钠和钾排泄以及γ-谷氨酰转移酶活性。结果- 基线时，平均（SD）收缩压/舒张压常规血压为130（17）/77（9）mm Hg。平均血铅浓度为0.42 μmol/L（8.7 μg/dL），平均锌原卟啉浓度为1.0 μg/g血红蛋白。在5.2年的中位随访中，平均血铅浓度下降了32%（0.14 μmol/L [2.9 μg/dL]）（P - 在所研究的强度下的铅暴露（
Objective. —To evaluate in a prospective fashion the association between low-level lead exposure and blood pressure. Design. —Prospective cohort study. Setting. —General population. Participants. —A random population sample (N=728; 49% men; age range, 20-82 years) was studied in Belgium for 1985 through 1989 and reexamined for 1991 through 1995. Mean Outcome Measures. —At baseline and follow-up, blood pressure was measured by conventional sphygmomanometry (15 total readings) and at followup also by 24-hour ambulatory monitoring. Lead exposure was estimated from blood lead and zinc protoporphyrin concentrations. Multivariate analyses controlled for sex, age, body mass index, smoking and drinking habits, physical activity, exposure at work, social class, menopausal status, use of medications (antihypertensive medication, oral contraceptives, hormonal replacement therapy), hematocrit or hemoglobin, serum total calcium concentration, 24-hour urinary sodium and potassium excretion, and γ-glutamyltransferase activity. Results. —At baseline, mean (SD) systolic/diastolic conventional blood pressure was 130 (17)/77 (9) mm Hg. The mean blood lead concentration was 0.42 μmol/L (8.7 μg/dL), and the mean zinc protoporphyrin concentration was 1.0 μg per gram of hemoglobin. Over the 5.2-year median follow-up, the mean blood lead concentration dropped by 32% (0.14 μmol/L [2.9 μg/dL]) (P Conclusions. —Lead exposure at the intensity studied (
妊娠期高血压、分娩时血压和血铅水平。
DOI：
10.1161/01.hyp.10.4.447
发表时间：
1987
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
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作者：
Rabinowitz,M;Bellinger,D;Leviton,A;Needleman,H;Schoenbaum,S
通讯作者：
Schoenbaum,S
对职业男性的纵向研究显示血液与血压的关系。
影响因子：
5
作者：
Weiss,ST;Muñoz,A;Stein,A;Sparrow,D;Speizer,FE
通讯作者：
Speizer,FE