Pregnancy hypertension, blood pressure during labor, and blood lead levels.
Pregnancy hypertension, blood pressure during labor, and blood lead levels.
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妊娠期高血压、分娩时血压和血铅水平。
DOI：
10.1161/01.hyp.10.4.447
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schoenbaum,S
中科院分区：
文献类型：
--
作者：
Rabinowitz,M;Bellinger,D;Leviton,A;Needleman,H;Schoenbaum,S
在3851名妇女中评估了妊娠高血压、分娩时血压和脐带血铅浓度，这些妇女有额外的人口统计学、医疗和个人信息。铅水平与收缩压（Pearson r = 0.081，p = 0.0001）和舒张压（r = 0.051，p = 0.002）相关。妊娠期高血压的发生率随铅水平的升高而升高。妊娠高血压和收缩压作为母亲年龄、产次、红细胞压积、体重指数、种族和糖尿病的函数的多变量模型通过包括铅作为预测变量而得到改进。在这些观察到的暴露水平（平均血铅，6.9 +/- 3.3 [SD]微克/分升），铅似乎与妊娠高血压和分娩时的血压有一个小的，但可证实的关联，但与先兆子痫无关。
Pregnancy hypertension, blood pressure during labor, and the umbilical cord blood lead concentration were assessed in 3851 women for whom additional demographic, medical, and personal information was available. Lead levels correlated with both systolic (Pearson r = 0.081, p = 0.0001) and diastolic (r = 0.051, p = 0.002) blood pressures during labor. The incidence of pregnancy hypertension increased with lead level. Multivariate models of pregnancy hypertension and systolic blood pressure as a function of maternal age, parity, hematocrit, ponderal index, race, and diabetes were improved by including lead as a predictor variable. At these observed levels of exposure (mean blood lead, 6.9 +/- 3.3 [SD] micrograms/dl), lead appears to have a small but demonstrable association with pregnancy hypertension and blood pressure at the time of delivery, but not with preeclampsia.
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