Disruption of Mitotic Progression by Arsenic.
Disruption of Mitotic Progression by Arsenic.
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DOI：
10.1007/s12011-015-0306-7
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发表时间：
2015-07
影响因子：
3.9
通讯作者：
States JC
中科院分区：
文献类型：
--
作者：
States JC
砷是一种神秘的异生素，会导致包括癌症在内的多种慢性疾病，也是一种有望治疗癌症的药物。砷会导致有丝分裂延迟并诱导二倍体人类细胞的非整倍性。相比之下，砷会导致有丝分裂停滞，随后导致大量病毒转化细胞和癌细胞凋亡。我们探讨了这样的假设：砷暴露的这些不同影响与砷对有丝分裂的破坏有关，并通过靶细胞调节或修改细胞周期检查点的能力而区分。功能性 p53/CDKN1A 轴已被证明可以减轻有丝分裂阻滞，并且对于诱导非整倍性至关重要。最近的初步数据表明，微小RNA对染色单体凝聚力的调节也可能在逃离有丝分裂阻滞和染色体不稳定性的产生中发挥作用。其他最近的研究表明，当砷与其他细胞毒性药物（例如顺铂）联合使用时，可能有助于治疗实体瘤。
Arsenic is an enigmatic xenobiotic that causes a multitude of chronic diseases including cancer and also is a therapeutic with promise in cancer treatment. Arsenic causes mitotic delay and induces aneuploidy in diploid human cells. In contrast, arsenic causes mitotic arrest followed by an apoptotic death in a multitude of virally transformed cells and cancer cells. We have explored the hypothesis that these differential effects of arsenic exposure are related by arsenic disruption of mitosis and are differentiated by the target cell’s ability to regulate or modify cell cycle checkpoints. Functional p53/CDKN1A axis has been shown to mitigate the mitotic block and to be essential to induction of aneuploidy. More recent preliminary data suggest that microRNA modulation of chromatid cohesion also may play a role in escape from mitotic block and in generation of chromosomal instability. Other recent studies suggest that arsenic may be useful in treatment of solid tumors when used in combination with other cytotoxic agents such as cisplatin.
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影响因子：
4.3
作者：
Liu, Guo;Stevens, Joshua B.;Heng, Henry H.
通讯作者：
Heng, Henry H.
影响因子：
37.3
作者：
Ghosh P;Basu A;Singh KK;Giri AK
通讯作者：
Giri AK
影响因子：
6.4
作者：
Ghosh, P;Basu, A;Giri, AK
通讯作者：
Giri, AK
DOI：
10.1016/s1383-5742(97)00009-4
发表时间：
1997-06-01
影响因子：
5.3
作者：
Gonsebatt, ME;Vega, L;OstroskyWegman, P
通讯作者：
OstroskyWegman, P
影响因子：
4.3
作者：
Iland, Harry J.;Seymour, John F.
通讯作者：
Seymour, John F.