Nanomaterials for photo-based diagnostic and therapeutic applications.
Nanomaterials for photo-based diagnostic and therapeutic applications.
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DOI：
10.7150/thno.5327
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发表时间：
2013
期刊：
影响因子：
12.4
通讯作者：
Nguyen KT
中科院分区：
文献类型：
--
作者：
Menon JU;Jadeja P;Tambe P;Vu K;Yuan B;Nguyen KT
基于照片的诊断和治疗方法由于空间成像分辨率的提高、所涉及的微创方式以及局部治疗而日益突出。近年来，纳米粒子已被开发并应用于基于光的治疗应用。虽然一些纳米材料具有固有的基于光的成像能力，但包括聚合物纳米颗粒在内的其他纳米材料则充当纳米载体，为光成像和治疗应用提供各种荧光染料或光敏剂。这些应用可以从磁共振成像(MRI)和光学成像到光热疗法(PTT)和化疗。通常用于开发基于光的纳米粒子的材料从金属基(金、银和二氧化硅)到聚合物基(壳聚糖、葡聚糖、聚乙二醇(PEG)和聚乳酸-乙醇酸共聚(PLGA))。最近的研究已经为多模式“治疗和诊断”(治疗和诊断的结合)纳米载体铺平了道路，该载体能够使用细胞特异性配体进行主动靶向，并携带多种治疗和成像试剂，以实现准确的诊断和受控的药物输送。本文综述了目前用于合成基于光的纳米粒子的不同材料，它们的诊断和治疗应用，以及将这些新型纳米载体应用到临床实践中所面临的挑战。
Photo-based diagnosis and treatment methods are gaining prominence due to increased spatial imaging resolution, minimally invasive modalities involved as well as localized treatment. Recently, nanoparticles (NPs) have been developed and used in photo-based therapeutic applications. While some nanomaterials have inherent photo-based imaging capabilities, others including polymeric NPs act as nanocarriers to deliver various fluorescent dyes or photosensitizers for photoimaging and therapeutic applications. These applications can vary from Magnetic Resonance Imaging (MRI) and optical imaging to photothermal therapy (PTT) and chemotherapy. Materials commonly used for development of photo-based NPs ranges from metal-based (gold, silver and silica) to polymer-based (chitosan, dextran, poly ethylene glycol (PEG) and poly lactic-co-glycolic acid (PLGA)). Recent research has paved the way for multi-modal 'theranostic' (a combination of therapy and diagnosis) nano-carriers capable of active targeting using cell-specific ligands and carrying multiple therapeutic and imaging agents for accurate diagnosis and controlled drug delivery. This review summarizes the different materials used today to synthesize photo-based NPs, their diagnostic and therapeutic applications as well as the current challenges faced in bringing these novel nano-carriers into clinical practices.
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DOI：
10.1016/j.jconrel.2011.08.019
发表时间：
2011-12-20
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ding H;Yu H;Dong Y;Tian R;Huang G;Boothman DA;Sumer BD;Gao J
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影响因子：
10.3
作者：
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影响因子：
29.4
作者：
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通讯作者：
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影响因子：
--
作者：
Conde J;Doria G;Baptista P
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影响因子：
14
作者：
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通讯作者：
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