A Direct Demonstration of Functional Differences between Subdivisions of Human V5/MT.
A Direct Demonstration of Functional Differences between Subdivisions of Human V5/MT.
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DOI：
10.1093/cercor/bhw362
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
McKeefry DJ
中科院分区：
文献类型：
--
作者：
Strong SL;Silson EH;Gouws AD;Morland AB;McKeefry DJ
人类 V5/MT+ 的两个细分：一个位于后部 (MT/TO-1)，另一个位于更前部 (MST/TO-2)，使用功能性磁共振成像根据同侧与对侧视野的表征在人类参与者中进行识别。然后通过应用重复经颅磁刺激（rTMS）来破坏这些细分。 rTMS 被传送到皮质区域，同时参与者执行方向辨别任务，涉及由点图案的平移、径向或旋转运动定义的 3 种不同类型的移动刺激。对于平移运动，当 rTMS 应用于 MT/TO-1 和 MST/TO-2 时，性能相对于基线显着降低。对于径向运动，MT/TO-1 和 MST/TO-2 之间存在差异效应，仅破坏后者区域会影响性能。 rTMS 未能揭示 MT/TO-1 和 MST/TO-2 在对旋转运动感知的贡献方面完全分离。根据这些结果，MT/TO-1 和 MST/TO-2 似乎是 hV5/MT+ 功能上不同的细分。虽然这两个区域似乎都与平移运动的处理有关，但只有前部区域 (MST/TO-2) 对径向运动的感知做出了因果贡献。
Two subdivisions of human V5/MT+: one located posteriorly (MT/TO-1) and the other more anteriorly (MST/TO-2) were identified in human participants using functional magnetic resonance imaging on the basis of their representations of the ipsilateral versus contralateral visual field. These subdivisions were then targeted for disruption by the application of repetitive transcranial magnetic stimulation (rTMS). The rTMS was delivered to cortical areas while participants performed direction discrimination tasks involving 3 different types of moving stimuli defined by the translational, radial, or rotational motion of dot patterns. For translational motion, performance was significantly reduced relative to baseline when rTMS was applied to both MT/TO-1 and MST/TO-2. For radial motion, there was a differential effect between MT/TO-1 and MST/TO-2, with only disruption of the latter area affecting performance. The rTMS failed to reveal a complete dissociation between MT/TO-1 and MST/TO-2 in terms of their contribution to the perception of rotational motion. On the basis of these results, MT/TO-1 and MST/TO-2 appear to be functionally distinct subdivisions of hV5/MT+. While both areas appear to be implicated in the processing of translational motion, only the anterior region (MST/TO-2) makes a causal contribution to the perception of radial motion.
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影响因子：
14.5
作者：
BECKERS, G;ZEKI, S
通讯作者：
ZEKI, S
影响因子：
2.5
作者：
DUFFY, CJ;WURTZ, RH
通讯作者：
WURTZ, RH
影响因子：
2.5
作者：
Eifuku, S;Wurtz, RH
通讯作者：
Wurtz, RH
影响因子：
2
作者：
Cowey, Alan;Campana, Gianluca;Vaina, Lucia M.
通讯作者：
Vaina, Lucia M.
关于可能事物的感知：关联记忆，图像和感知的神经底物。
影响因子：
16.2
作者：
Albright TD
通讯作者：
Albright TD