Evolution of herpes simplex virus type 1 under herpesviral evolutionary processes-猫眼课题宝

单纯疱疹病毒1型在疱疹病毒进化过程中的进化

DOI：

发表时间：

1999

期刊：

Archives of Virology

影响因子：

2.7

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

K. Umene;H. Sakaoka

疱疹病毒的基因组是由120个或更多个双链DNA组成的双链DNA，感染从哺乳动物到鱼类的多种脊椎动物。单纯疱疹病毒1型（HSV-1）是疱疹病毒科的代表，是人类普遍存在的病原体。HSV-1与常见的粘膜皮肤疾病有关，而HSV-1感染可能意味着严重的后果，例如失明和对中枢神经系统的损害。疱疹病毒的进化包括DNA重排，通常产生串联或反向重复序列。HSV-1 DNA动力学的研究证实了这些DNA重组过程参与疱疹病毒的进化。疱疹病毒似乎已经从一个共同的祖先多样化，在某种程度上介导的共同物种的疱疹病毒与宿主物种通过物种特异性潜伏感染。因此，疱疹病毒的宿主相关进化的概念得到了支持。HSV-1基因型和人类种族群体之间的关系可以通过分析不同国家人群中存在的HSV-1毒株的DNA多态性来追踪。HSV-1基因型与特定历史人群的密切关联似乎是可能的。在这种情况下，宿主连接模式可能与人类群体中HSV-1的多样化有关。

SummaryHerpesviruses, the genomes of which are double-stranded DNA of 120 kilobase pairs or more, infect a wide range of vertebrates from mammals to fish. Herpes simplex virus type 1 (HSV-1), a representative of family Herpesviridae, is a ubiquitous human pathogen. HSV-1 relates to common muco-cutaneous diseases, while HSV-1 infection can mean a serious outcome, e.g. blindness and insult to the central nervous system. Evolution of herpesviruses includes DNA rearrangements, often generating tandemly or invertedly repeated sequences. Studies of HSV-1 DNA dynamics substantiated these processes of DNA recombination involved in the evolution of herpesvirus. Herpesviruses seem to have diversified from a common ancestor, in a manner mediating co-speciation of herpesviruses with host species through species-specific latent infections. Thus, the notion of host-linked evolution of herpesviruses is given support. Relationships between HSV-1 genotypes and human ethnic groups can be traced by analyses of DNA polymorphisms of HSV-1 strains present in populations of various countries. A close association of an HSV-1 genotype with a particular historical human population seems probable. Such being the case, the host-linked mode is likely to be linked to diversification of HSV-1 in human populations.