The role of necrotic cell death in the pathogenesis of immune mediated nephropathies.

The role of necrotic cell death in the pathogenesis of immune mediated nephropathies.
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DOI:
10.1016/j.clim.2014.05.002
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发表时间:
2014-08
期刊:
Clinical immunology (Orlando, Fla.)
影响因子:
--
通讯作者:
Caricchio R
Caricchio R
中科院分区:
其他
文献类型:
--
作者:
Jog NR;Caricchio R

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Necrosis, an inflammatory form of cell death, has been considered to be an accidental death and/or cell death due to injury. However, the literature in the last decade has established that necrosis is a regulated form of cell death, and that inhibition of specific molecular pathways leading to necrosis can block it and reduce inflammation. Since necrotic lesions are observed in several immune mediated human pathologies, in this review we will discuss the impact that this form of programmed cellular demise has in the pathology of immune mediated nephropathies.
通过下调炎症和Th1反应,聚(ADP-核糖)聚合酶1抑制剂对实验性关节炎的治疗作用。
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