Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditions.
Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditions.
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DOI：
10.1186/1297-9686-41-54
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发表时间：
2009-12-30
期刊：
影响因子：
--
通讯作者：
Bishop SC
中科院分区：
文献类型：
--
作者：
Clapperton M;Diack AB;Matika O;Glass EJ;Gladney CD;Mellencamp MA;Hoste A;Bishop SC
需要遗传标记或生物标记来预测对各种传染病的抵抗力，特别是在商业农场典型的健康环境中。这些标记还需要在这些条件下是可遗传的，并理想地与商业性能性状相关。在这项研究中，我们估计了作为潜在生物标志物的一系列免疫性状的遗传力，并测量了它们与无特定病原体(SPF)和非SPF环境下表现的关系。对674头SPF猪和606头非SPF猪的免疫性状进行了测量，这些猪是我们进行性能测量(平均日增重)的群体的子集，即。1549头SPF猪和1093头非SPF猪。免疫指标包括白细胞总数和分类、外周血单核细胞亚群(CD_4+细胞、CD_8α+细胞、经典CD_8αβ+细胞、CD_11R_1+细胞(CD_8α+和CD_8α-)、B细胞、单核细胞和CD_(16)+细胞)和急性期蛋白(α-1酸性糖蛋白、结合珠蛋白、C反应蛋白和转甲状腺素)。几乎所有测试的性状都是可遗传的，无论健康状况如何，尽管在非SPF条件下平均日增重的遗传力估计较低。免疫指标：CD11R1+细胞、单核细胞和急性时相蛋白AGP与生产性能呈负相关。健康状况不影响表现和AGP之间的关联强度。然而，只有在SPF条件下表现与单核细胞之间以及在非SPF条件下表现与CD11R1+细胞之间存在负遗传相关。虽然我们不能在这些关系中推断因果关系，但这些结果表明，使用一些免疫性状，特别是CD11R1+细胞或AGP浓度，作为商业农场较低健康状况下猪生产性能的预测因子。
There is a need for genetic markers or biomarkers that can predict resistance towards a wide range of infectious diseases, especially within a health environment typical of commercial farms. Such markers also need to be heritable under these conditions and ideally correlate with commercial performance traits. In this study, we estimated the heritabilities of a wide range of immune traits, as potential biomarkers, and measured their relationship with performance within both specific pathogen-free (SPF) and non-SPF environments. Immune traits were measured in 674 SPF pigs and 606 non-SPF pigs, which were subsets of the populations for which we had performance measurements (average daily gain), viz. 1549 SPF pigs and 1093 non-SPF pigs. Immune traits measured included total and differential white blood cell counts, peripheral blood mononuclear leucocyte (PBML) subsets (CD4+ cells, total CD8α+ cells, classical CD8αβ+ cells, CD11R1+ cells (CD8α+ and CD8α-), B cells, monocytes and CD16+ cells) and acute phase proteins (alpha-1 acid glycoprotein (AGP), haptoglobin, C-reactive protein (CRP) and transthyretin). Nearly all traits tested were heritable regardless of health status, although the heritability estimate for average daily gain was lower under non-SPF conditions. There were also negative genetic correlations between performance and the following immune traits: CD11R1+ cells, monocytes and the acute phase protein AGP. The strength of the association between performance and AGP was not affected by health status. However, negative genetic correlations were only apparent between performance and monocytes under SPF conditions and between performance and CD11R1+ cells under non-SPF conditions. Although we cannot infer causality in these relationships, these results suggest a role for using some immune traits, particularly CD11R1+ cells or AGP concentrations, as predictors of pig performance under the lower health status conditions associated with commercial farms.
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影响因子：
4.8
作者：
Hochepied, T;Van Molle, W;Libert, C
通讯作者：
Libert, C
影响因子：
3.3
作者：
ALLAN, GM;MCNEILLY, F;ADAIR, BM
通讯作者：
ADAIR, BM
DOI：
10.1073/pnas.0709681104
发表时间：
2007-12-04
影响因子：
11.1
作者：
Mestriner, F. L. A. C.;Spiller, F.;Cunha, F. Q.
通讯作者：
Cunha, F. Q.
影响因子：
4.3
作者：
ALLER, SC;CHO, DH;KIM, YB
通讯作者：
KIM, YB
影响因子：
1.8
作者：
Haverson, K;Bailey, M;Ledbetter, JA
通讯作者：
Ledbetter, JA