GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons.
GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons.
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DOI：
10.1038/nn.2984
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发表时间：
2011-12-11
影响因子：
25
通讯作者：
Koos T
中科院分区：
文献类型：
--
作者：
English DF;Ibanez-Sandoval O;Stark E;Tecuapetla F;Buzsáki G;Deisseroth K;Tepper JM;Koos T
新纹状体胆碱能中间神经元被认为在强化介导的学习和反应选择中发挥着重要作用，通过精确定时的多相群体反应来发出行为相关刺激的发生和动机价值的信号。一个重要的问题是了解这些信号如何调节新纹状体的功能。在这里，我们描述了一种新颖电路的突触组织，该电路涉及 GABA 能中间神经元的直接烟碱激发，并使胆碱能中间神经元能够对投射神经元的活动进行快速抑制控制。我们还证明，胆碱能中间神经元的光遗传学再现的暂停-兴奋群体反应的主导效应是对与同步胆碱能激活同时发生的投射神经元的放电的强大而快速的抑制。这些结果揭示了一种先前未知的电路机制，该机制在小鼠新纹状体网络中传递 ChAT 中间神经元的强化相关信息。
Neostriatal cholinergic interneurons are believed to play an important role in reinforcement mediated learning and response selection by signaling the occurrence and motivational value of behaviorally relevant stimuli through precisely timed multiphasic population responses. An important problem is to understand how these signals regulate the functioning of the neostriatum. Here we describe the synaptic organization of a novel circuit that involves direct nicotinic excitation of GABAergic interneurons and enables cholinergic interneurons to exert rapid inhibitory control of the activity of projection neurons. We also demonstrate that the dominant effect of an optogenetically reproduced pause-excitation population response of cholinergic interneurons is powerful and rapid inhibition of the firing of projection neurons that is coincident with synchronous cholinergic activation. These results reveal a previously unknown circuit mechanism that transmits reinforcement-related information of ChAT interneurons in the mouse neostriatal network.
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DOI：
10.1523/jneurosci.2192-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Berke JD
通讯作者：
Berke JD
影响因子：
2.5
作者：
Apicella, P;Ravel, S;Legallet, E
通讯作者：
Legallet, E
DOI：
10.1073/pnas.81.15.4998
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
KIMURA, M;RAJKOWSKI, J;EVARTS, E
通讯作者：
EVARTS, E
影响因子：
5.3
作者：
Banks, MI;Pearce, RA
通讯作者：
Pearce, RA
影响因子：
3
作者：
Jog, MS;Connolly, CI;Graybiel, AM
通讯作者：
Graybiel, AM