Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk.
Progressive reduction in cortical thickness as psychosis develops: a multisite longitudinal neuroimaging study of youth at elevated clinical risk.
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DOI：
10.1016/j.biopsych.2014.05.023
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发表时间：
2015-01-15
影响因子：
10.6
通讯作者：
Heinssen, Robert
中科院分区：
文献类型：
--
作者：
Cannon, Tyrone D.;Chung, Yoonho;He, George;Sun, Daqiang;Jacobson, Aron;van Erp, Theo G. M.;McEwen, Sarah;Addington, Jean;Bearden, Carrie E.;Cadenhead, Kristin;Cornblatt, Barbara;Mathalon, Daniel H.;McGlashan, Thomas;Perkins, Diana;Jeffries, Clark;Seidman, Larry J.;Tsuang, Ming;Walker, Elaine;Woods, Scott W.;Heinssen, Robert
Individuals at clinical high-risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with those without symptomatic progression and with healthy controls. Whether such changes reflect processes associated with the pathophysiology of schizophrenia or exposure to antipsychotic drugs is unknown. In this multisite study, 274 CHR cases, including 35 who converted to psychosis, and 135 healthy comparison subjects were scanned with MRI at baseline, 12-month follow-up, and/or the point of conversion for those who developed fully psychotic symptoms. In a traveling subjects sub-study, we observed excellent reliability for measures of cortical thickness and subcortical volumes. Controlling for multiple comparisons throughout the brain, CHR converters showed a steeper rate of gray matter loss in right superior frontal, middle frontal, and medial orbitofrontal cortical regions, as well as a greater rate of expansion of the third ventricle, compared with CHR non-converters and healthy controls. Differential tissue loss was present among cases who had not received antipsychotic medications during the inter-scan interval and was predicted by baseline levels of an aggregate measure of pro-inflammatory cytokines in plasma. These findings demonstrate that the brain changes are not explained by exposure to antipsychotic drugs, but likely play a role in psychosis pathophysiology. Given that the cortical changes were more pronounced among cases with briefer durations of prodromal symptoms, contributing factors may predominantly play a role in acute-onset forms of psychosis.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.3
作者：
Glausier, J. R.;Lewis, D. A.
通讯作者：
Lewis, D. A.
影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
3.8
作者：
Gunter, Jeffrey L.;Bernstein, Matt A.;Jack, Clifford R.
通讯作者：
Jack, Clifford R.
影响因子：
4.8
作者：
Cannon, Tyrone D.;Sun, Frank;McEwen, Sarah Jacobson;Papademetris, Xenophon;He, George;van Erp, Theo G. M.;Jacobson, Aron;Bearden, Carrie E.;Walker, Elaine;Hu, Xiaoping;Zhou, Lei;Seidman, Larry J.;Thermenos, Heidi W.;Cornblatt, Barbara;Olvet, Doreen M.;Perkins, Diana;Belger, Aysenil;Cadenhead, Kristin;Tsuang, Ming;Mirzakhanian, Heline;Addington, Jean;Frayne, Richard;Woods, Scott W.;McGlashan, Thomas H.;Constable, R. Todd;Qiu, Maolin;Mathalon, Daniel H.;Thompson, Paul;Toga, Arthur W.
通讯作者：
Toga, Arthur W.