Reliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis.
Reliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis.
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DOI：
10.1002/hbm.22338
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Toga, Arthur W.
中科院分区：
文献类型：
--
作者：
Cannon, Tyrone D.;Sun, Frank;McEwen, Sarah Jacobson;Papademetris, Xenophon;He, George;van Erp, Theo G. M.;Jacobson, Aron;Bearden, Carrie E.;Walker, Elaine;Hu, Xiaoping;Zhou, Lei;Seidman, Larry J.;Thermenos, Heidi W.;Cornblatt, Barbara;Olvet, Doreen M.;Perkins, Diana;Belger, Aysenil;Cadenhead, Kristin;Tsuang, Ming;Mirzakhanian, Heline;Addington, Jean;Frayne, Richard;Woods, Scott W.;McGlashan, Thomas H.;Constable, R. Todd;Qiu, Maolin;Mathalon, Daniel H.;Thompson, Paul;Toga, Arthur W.
关键词：
多位点纵向神经影像学设计用于识别与发病或疾病进展相关的脑结构变化差异。在这些研究中，神经解剖学测量随时间和跨部位的可靠性是一个至关重要的方面。先前的工作已经发现，虽然神经解剖学测量的站点内可靠性很好，但站点之间的可靠性通常比较温和。可能增加站点间可靠性的因素包括扫描仪平台和序列参数的标准化以及对扫描仪间梯度非线性变化的校正。可能提高位点间和位点内可靠性的因素包括使用解释皮质模式和形状个体差异的配准算法。在这项研究中，8名健康志愿者在8个参与北美前驱期纵向研究（NAPLS）的地点连续两天进行了两次扫描。所有站点均采用3台Tesla扫描仪和标准化采集参数。部位占神经解剖学测量总方差的2 - 30%。然而，在使用相同扫描仪模型和12通道线圈的位点之间，或者在校正梯度非线性和缩放的扫描仪之间的差异时，位点相关的变化微不足道（<1%）。调整脑沟-脑回几何形状的个体差异产生的测量结果比使用自动化方法获得的测量结果更可靠。神经成像可以在多个部位进行，可靠性水平与在单个部位相同，对于前额叶和颞叶皮层表面的大多数体素的灰质密度以及大多数皮层下结构的体积，在位点内和位点之间实现0.95或更高的可靠性。
Multi-site longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within-site reliabilities of neuroanatomical measurements are excellent, between-site reliability is generally more modest. Factors that may increase between-site reliability include standardization of scanner platform and sequence parameters and correction for between-scanner variations in gradient nonlinearities. Factors that may improve both between- and within-site reliability include use of registration algorithms that account for individual differences in cortical patterning and shape. In this study 8 healthy volunteers were scanned twice on successive days at 8 sites participating in the North American Prodrome Longitudinal Study (NAPLS). All sites employed 3 Tesla scanners and standardized acquisition parameters. Site accounted for 2 to 30% of the total variance in neuroanatomical measurements. However, site-related variations were trivial (<1%) among sites using the same scanner model and 12-channel coil or when correcting for between-scanner differences in gradient nonlinearity and scaling. Adjusting for individual differences in sulcal-gyral geometries yielded measurements with greater reliabilities than those obtained using an automated approach. Neuroimaging can be performed across multiple sites at the same level of reliability as at a single site, achieving within- and between-site reliabilities of 0.95 or greater for gray matter density in the majority of voxels in the prefrontal and temporal cortical surfaces as well as for the volumes of most subcortical structures.
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影响因子：
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作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
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