Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
Pan-cancer analysis of oncogenic TNFAIP2 identifying its prognostic value and immunological function in acute myeloid leukemia.
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致癌性 TNFAIP2 的泛癌分析确定其在急性髓系白血病中的预后价值和免疫功能
DOI：
10.1186/s12885-022-10155-9
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发表时间：
2022-10-15
期刊：
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
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作者：
肿瘤坏死因子α诱导蛋白2 （TNFAIP2）是一种tnf α诱导基因，参与炎症、免疫反应、造血和癌变。然而，TNFAIP2在急性髓性白血病（AML）发展中的潜在作用尚不清楚。因此，我们旨在研究TNFAIP2在白血病发生中的生物学作用。通过多个公共数据库，包括UALCAN、GTEx portal、Timer 2.0、LinkedOmics、SMART、MethSurv、metscape、GSEA和String数据库，探讨AML患者TNFAIP2 mRNA水平、预后价值、共表达基因、差异表达基因、DNA甲基化和功能富集分析。来自癌症基因组图谱（TCGA）、基因表达图谱（GEO）和Beat AML数据库的数据被用来确定TNFAIP2表达与AML患者各种临床或遗传参数之间的关系。此外，通过体外实验研究了TNFAIP2在AML中的生物学功能。通过大规模的数据挖掘，我们的研究表明TNFAIP2在不同的正常组织和肿瘤组织中存在差异表达。与相应的对照组织相比，TNFAIP2在AML中的表达显著增加，特别是在法、美、英（FAB）分类的M4/M5患者中。TNFAIP2过表达是AML患者总生存期（OS）的一个独立的不良预后因素，并与不利的细胞遗传学风险和基因突变相关。AML患者TNFAIP2基因体DNA高甲基化与TNFAIP2上调和低OS相关功能富集分析显示TNFAIP2在白血病发生中的免疫调节功能和炎症反应。最后，在THP-1和U937AML细胞中，抑制TNFAIP通过改变细胞周期进程抑制增殖，并通过促进早期和晚期凋亡增加细胞死亡。总的来说，致癌的TNFAIP2可以作为AML患者的一种新的生物标志物和预后因素。TNFAIP2在AML中的免疫调节功能有待进一步验证。在线版本包含补充材料，可在10.1186/s12885-022-10155-9获得。
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), a TNFα-inducible gene, appears to participate in inflammation, immune response, hematopoiesis, and carcinogenesis. However, the potential role of TNFAIP2 in the development of acute myeloid leukemia (AML) remains unknow yet. Therefore, we aimed to study the biological role of TNFAIP2 in leukemogenesis. TNFAIP2 mRNA level, prognostic value, co-expressed genes, differentially expressed genes, DNA methylation, and functional enrichment analysis in AML patients were explored via multiple public databases, including UALCAN, GTEx portal, Timer 2.0, LinkedOmics, SMART, MethSurv, Metascape, GSEA and String databases. Data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Beat AML database were used to determine the associations between TNFAIP2 expression and various clinical or genetic parameters of AML patients. Moreover, the biological functions of TNFAIP2 in AML were investigated through in vitro experiments. By large-scale data mining, our study indicated that TNFAIP2 was differentially expressed across different normal and tumor tissues. TNFAIP2 expression was significantly increased in AML, particularly in French–American–British (FAB) classification M4/M5 patients, compared with corresponding control tissues. Overexpression of TNFAIP2 was an independent poor prognostic factor of overall survival (OS) and was associated with unfavorable cytogenetic risk and gene mutations in AML patients. DNA hypermethylation of TNFAIP2 at gene body linked to upregulation of TNFAIP2 and inferior OS in AML. Functional enrichment analysis indicated immunomodulation function and inflammation response of TNFAIP2 in leukemogenesis. Finally, the suppression of TNFAIP resulted in inhibition of proliferation by altering cell-cycle progression and increase of cell death by promoting early and late apoptosis in THP-1 and U937AML cells. Collectively, the oncogenic TNFAIP2 can function as a novel biomarker and prognostic factor in AML patients. The immunoregulation function of TNFAIP2 warrants further validation in AML. The online version contains supplementary material available at 10.1186/s12885-022-10155-9.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
7.5
作者：
Chen, Lih-Chyang;Chen, Chia-Chun;Hsueh, Chuen
通讯作者：
Hsueh, Chuen
影响因子：
64.5
作者：
Chevrier N;Mertins P;Artyomov MN;Shalek AK;Iannacone M;Ciaccio MF;Gat-Viks I;Tonti E;DeGrace MM;Clauser KR;Garber M;Eisenhaure TM;Yosef N;Robinson J;Sutton A;Andersen MS;Root DE;von Andrian U;Jones RB;Park H;Carr SA;Regev A;Amit I;Hacohen N
通讯作者：
Hacohen N
影响因子：
12.8
作者：
Ehninger, A.;Kramer, M.;Roellig, C.;Thiede, C.;Bornhaeuser, M.;von Bonin, M.;Wermke, M.;Feldmann, A.;Bachmann, M.;Ehninger, G.;Oelschlaegel, U.
通讯作者：
Oelschlaegel, U.
MicroRNA-184 抑制细胞增殖和侵袭，并特异性靶向胶质瘤中的 TNFAIP2
DOI：
10.1186/s13046-015-0142-9
发表时间：
2015-03-26
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Cheng Z;Wang HZ;Li X;Wu Z;Han Y;Li Y;Chen G;Xie X;Huang Y;Du Z;Zhou Y
通讯作者：
Zhou Y