Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.
Goal-striving tendencies moderate the relationship between reward-related brain function and peripheral inflammation.
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DOI：
10.1016/j.bbi.2021.03.006
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Alloy LB
中科院分区：
文献类型：
--
作者：
Chat IK;Nusslock R;Moriarity DP;Bart CP;Mac Giollabhui N;Damme KSF;Carroll AL;Miller GE;Alloy LB
炎症与处理奖赏刺激的大脑区域的活动减少和增加有关。对奖励的低敏感度和高敏感度如何都与更高的炎症有关？我们认为，这些明显相互矛盾的发现背后的一个潜在机制与人们如何在他们所处的环境中追求目标有关。这一预测基于的证据表明，无法摆脱无法实现的目标，以及对重要生活目标的兴趣和追求都与不良的健康结果有关，包括炎症。因此，这项研究考察了具有不同水平的雄心勃勃的目标追求倾向的个体的奖赏相关脑功能和外周炎症之间的关系。83名参与者完成了一项雄心勃勃的目标追求倾向测量，一项评估奖励预期和结果期间眶前皮质(OFC)和伏隔核(NAC)激活的fMRI货币激励延迟任务，以及一次静脉采血以评估炎症生物标志物白细胞介素6(IL)-6、IL-8、肿瘤坏死因子-α和C-反应蛋白，我们从中计算出炎症综合评分。我们观察到了通过目标追求对炎症的交互作用而产生的奖励预期，在高目标追求的个体中，高OFC和NAC激活来奖励预期(但不是结果)与更多的炎症有关。相比之下，在低目标追求的个体中，奖励预期(但不是结果)期间NAC的低激活与更多的炎症有关。目前的研究提供了进一步的证据表明，钝化和升高的奖励功能都可以与炎症相关。它还强调了目标追求倾向在调节神经奖赏预期和炎症之间的关系中可能发挥的作用。
Inflammation is associated with both lower and higher activity in brain regions that process rewarding stimuli. How can both low and high sensitivity to rewards be associated with higher inflammation? We propose that one potential mechanism underlying these apparently conflicting findings pertains to how people pursue goals in their environment. This prediction is based on evidence that both an inability to disengage from unattainable goals and low interest in and pursuit of important life goals are associated with poor health outcomes, including inflammation. Accordingly, this study examined the relationship between reward-related brain function and peripheral inflammation among individuals with different levels of ambitious goal-striving tendencies. Eighty-three participants completed an ambitious goal-striving tendency measure, an fMRI Monetary Incentive Delay task assessing orbitofrontal cortex (OFC) and nucleus accumbens (NAc) activation during reward anticipation and outcome, and a venous blood draw to assess the inflammatory biomarkers interleukin (IL)-6, IL-8, tumor necrosis factor-alpha, and C-reactive protein, from which we computed an inflammation composite score. We observed a reward anticipation by goal-striving interaction on inflammation, such that high OFC and NAc activation to reward anticipation (but not outcome) were associated with more inflammation, among high goal-striving individuals. By contrast, low NAc activation during reward anticipation (but not outcome) was associated with more inflammation, among low goal-striving individuals. The current study provides further evidence that both blunted and elevated reward function can be associated with inflammation. It also highlights the role that goal-striving tendencies may play in moderating the relationship between neural reward anticipation and inflammation.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
影响因子：
11
作者：
Haroon E;Fleischer CC;Felger JC;Chen X;Woolwine BJ;Patel T;Hu XP;Miller AH
通讯作者：
Miller AH
关于炎症如何增强对惩罚与奖励的敏感性的神经计算说明。
影响因子：
10.6
作者：
Harrison NA;Voon V;Cercignani M;Cooper EA;Pessiglione M;Critchley HD
通讯作者：
Critchley HD
影响因子：
3.7
作者：
Forbes EE;Rodriguez EE;Musselman S;Narendran R
通讯作者：
Narendran R
影响因子：
--
作者：
Capuron L;Pagnoni G;Drake DF;Woolwine BJ;Spivey JR;Crowe RJ;Votaw JR;Goodman MM;Miller AH
通讯作者：
Miller AH