Attentional Changes in Either Criterion or Sensitivity Are Associated with Robust Modulations in Lateral Prefrontal Cortex.
Attentional Changes in Either Criterion or Sensitivity Are Associated with Robust Modulations in Lateral Prefrontal Cortex.
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DOI：
10.1016/j.neuron.2018.02.007
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发表时间：
2018-03-21
期刊：
影响因子：
16.2
通讯作者：
Maunsell JHR
中科院分区：
文献类型：
--
作者：
Luo TZ;Maunsell JHR
视觉注意力与整个大脑的神经元变化有关，这些广泛的信号通常被认为是单一注意力机制的基础。然而，注意力相关对表现的影响可以使用信号检测理论划分为受试者标准或敏感性的变化。先前在视觉皮层中观察到仅与敏感性变化相关的神经元调节，提出了哪些结构介导与注意力相关的标准变化以及单个神经元是否参与注意力的多个组成部分的问题。在这里，我们从猴子外侧前额叶皮层 (LPFC) 进行记录，发现与视觉皮层相比，当受试者改变其标准或敏感性时，LPFC 中的神经元会改变其放电率、成对相关性和 Fano 因子。这些结果表明，不同大脑区域中与注意力相关的神经元调节并不是一个单一的信号，而是可能与不同的行为变化相关。罗和莫恩塞尔表明，前额叶皮层的调节对应于注意力的多个组成部分，并且与视觉皮层的调节不同，这表明不同的大脑结构构成了不同的注意力机制，并且注意力不是一个单一的过程。
Visual attention is associated with neuronal changes across the brain, and these widespread signals are generally assumed to underlie a unitary mechanism of attention. However, attention-related effects on performance can be partitioned using signal detection theory into changes in either the subject’s criterion or sensitivity. Neuronal modulations associated with only sensitivity changes were previously observed in visual cortex, raising the questions of which structures mediate attention-related changes in criterion and whether individual neurons are involved in multiple components of attention. Here we recorded from monkey lateral prefrontal cortex (LPFC) and found that in contrast to visual cortex, neurons in LPFC changed their firing rates, pairwise correlation, and Fano factor when the subject changed either its criterion or its sensitivity. These results indicate that attention-related neuronal modulations in separate brain regions are not a monolithic signal and instead can be linked to distinct behavioral changes. Luo and Maunsell show that the modulations in prefrontal cortex correspond to multiple components of attention and differ from modulations in visual cortex, indicating that different brain structures underlie distinct attentional mechanisms and that attention is not a unitary process.
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