Anti-retroviral treatment outcomes among older adults in Zomba district, Malawi.
Anti-retroviral treatment outcomes among older adults in Zomba district, Malawi.
复制标题
DOI：
10.1371/journal.pone.0026546
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Cumming RG
中科院分区：
文献类型：
--
作者：
Negin J;van Lettow M;Semba M;Martiniuk A;Chan A;Cumming RG
在撒哈拉以南非洲，大约有300万50岁及以上的人艾滋病毒呈阳性。尽管如此，人们对正在接受治疗的老年人的特征及其治疗结果知之甚少。使用马拉维卫生部监测工具从Zomba区提供抗逆转录病毒治疗服务的设施收集的常规数据进行了回溯性队列分析。纳入2005年7月至2010年6月开始接受治疗的25岁及以上患者。采用Kaplan-Meier生存图和Cox比例风险回归模型，确定不同年龄组的生存差异。共有10,888名年龄在25岁及以上的患者。与25-49岁的患者相比，50岁及以上的患者(N = 1419)更有可能是男性(P<；0.0001)，并且位于农村地区(P = 0.003)。年龄在50-59岁和25-49岁的患者的粗略生存估计值无统计学差异(P = 0.925)。然而，60岁及以上人群(N = 345)的存活率比25-59岁人群差(P = 0.019)。在比例风险模型中，在控制了性别和发病阶段后，年龄在50-59岁和25-49岁的患者的存活率没有显著差异(危险比1.00(95%CI：0.79~1.2 7；P = 0.998)，但60岁及以上的风险比为1.46(95%CI：1.0 3~2.0 6；P = 0.032)。50-59岁患者的治疗结果与25-49岁患者相似。更好地了解老年人如何接受治疗并对治疗作出反应，对于改善艾滋病毒服务至关重要。
There are approximately 3 million people aged 50 and older in sub-Saharan Africa who are HIV-positive. Despite this, little is known about the characteristics of older adults who are on treatment and their treatment outcomes. A retrospective cohort analysis was performed using routinely collected data with Malawi Ministry of Health monitoring tools from facilities providing antiretroviral therapy services in Zomba district. Patients aged 25 years and older initiated on treatment from July 2005 to June 2010 were included. Differences in survival, by age group, were determined using Kaplan–Meier survival plots and Cox proportional hazards regression models. There were 10,888 patients aged 25 and older. Patients aged 50 and older (N = 1419) were more likely to be male (P<0.0001) and located in rural areas (P = 0.003) than those aged 25–49. Crude survival estimates among those aged 50–59 were not statistically different from those aged 25–49 (P = 0.925). However, survival among those aged 60 and older (N = 345) was worse (P = 0.019) than among those 25–59. In the proportional hazards model, after controlling for sex and stage at initiation, survival in those aged 50–59 did not differ significantly from those aged 25–49 (hazard ratio 1.00 (95% CI: 0.79 to 1.27; P = 0.998) but the hazard ratio was 1.46 (95% CI: 1.03 to 2.06; P = 0.032) for those aged 60 and older compared to those aged 25–49. Treatment outcomes of those aged 50–59 are similar to those aged 25–49. A better understanding of how older adults present for and respond to treatment is critical to improving HIV services.
登录
查看更多内容
影响因子：
11.8
作者：
Grimes, RM;Otiniano, ME;Lai, DJ
通讯作者：
Lai, DJ
影响因子：
168.9
作者：
Babiker, A;Darby, S;Schechter, M
通讯作者：
Schechter, M
影响因子：
7.2
作者：
Ettenhofer, Mark L.;Hinkin, Charles H.;Foley, Jessica
通讯作者：
Foley, Jessica
影响因子：
4.6
作者：
Justice, Amy C
通讯作者：
Justice, Amy C
影响因子：
3.8
作者：
Goetz, MB;Boscardin, WJ;Alkasspooles, S
通讯作者：
Alkasspooles, S