The immune response in glaucoma: a perspective on the roles of oxidative stress.
The immune response in glaucoma: a perspective on the roles of oxidative stress.
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DOI：
10.1016/j.exer.2010.07.009
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发表时间：
2011-08
影响因子：
3.4
通讯作者：
Tezel, Guelguen
中科院分区：
文献类型：
--
作者：
Tezel, Guelguen
神经退行性损伤和神经胶质细胞活化在脑水肿性神经变性启动免疫反应，以恢复组织稳态，促进组织清洁和愈合。然而，在慢性和累积期内增加的风险因素可能导致先天性和适应性免疫应答途径的调节失败，并代表了将有益免疫转化为促进疾病进展的神经炎性退行性过程的途径。通过青光眼的致病细胞过程发展的氧化应激，沿着氧化应激的老化相关组分，可能在改变生理平衡中起关键作用。这篇综述旨在通过提出一个统一的方案，将氧化应激相关的危险因素与青光眼免疫反应调节的改变相结合，为青光眼神经变性过程中细胞事件的复杂相互作用提供一个视角。
Neurodegenerative insults and glial activation during glaucomatous neurodegeneration initiate an immune response to restore tissue homeostasis and facilitate tissue cleaning and healing. However, increasing risk factors over a chronic and cumulative period may lead to a failure in the regulation of innate and adaptive immune response pathways and represent a route for conversion of the beneficial immunity into a neuroinflammatory degenerative process contributing to disease progression. Oxidative stress developing through the pathogenic cellular processes of glaucoma, along with the aging-related component of oxidative stress, likely plays a critical role in shifting the physiological equilibrium. This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration by proposing a unifying scheme that integrates oxidative stress-related risk factors with the altered regulation of immune response in glaucoma.
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