Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.
Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.
复制标题
DOI：
10.1016/j.biomaterials.2013.05.003
复制
发表时间：
2013-09
期刊：
影响因子：
14
通讯作者：
Kopecek, Jindrich
中科院分区：
文献类型：
--
作者：
Pan, Huaizhong;Sima, Monika;Miller, Scott C.;Kopeckova, Pavla;Yang, Jiyuan;Kopecek, Jindrich
关键词：
Multiblock, high molecular weight, linear, backbone degradable HPMA copolymer-prostaglandin E1 (PGE1) conjugate has been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA), which contains an enzymatically degradable oligopeptide sequence flanked by two dithiobenzoate groups, followed by post-polymerization aminolysis and thiol-ene chain extension. The multiblock conjugate contains Asp8 as the bone-targeting moiety and enzymatically degradable bonds in the polymer backbone; in vivo degradation produces cleavage products that are below the renal threshold. Using an ovariectomized (OVX) rat model, the accumulation in bone and efficacy to promote bone formation was evaluated; low molecular weight conjugates served as control. The results indicated a higher accumulation in bone, greater enhancement of bone density, and higher plasma osteocalcin levels for the backbone degradable conjugate.
登录
查看更多内容
影响因子：
5.5
作者：
Luo K;Yang J;Kopečková P;Kopeček J
通讯作者：
Kopeček J
影响因子：
4.5
作者：
Pan, Huaizhong;Kopeckova, Pavla;Kopecek, Jindrich
通讯作者：
Kopecek, Jindrich
影响因子：
16.1
作者：
Kopecek, Jindrich
通讯作者：
Kopecek, Jindrich
DOI：
10.1002/jbm.820211106
发表时间：
1987-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
SEYMOUR, LW;DUNCAN, R;KOPECEK, J
通讯作者：
KOPECEK, J
长循环的，可降解的HPMA共聚物 - 道霉素结合物的合成以及分子量依赖性抗肿瘤功效的评估。
影响因子：
4.6
作者：
Pan H;Sima M;Yang J;Kopeček J
通讯作者：
Kopeček J