Factors associated with severe dengue in Savannakhet Province, Lao People's Democratic Republic.
Factors associated with severe dengue in Savannakhet Province, Lao People's Democratic Republic.
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老挝人民民主共和国萨凡纳克海特省的严重登革热有关的因素。
DOI：
10.18999/nagjms.83.4.749
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发表时间：
2021-11
影响因子：
0.9
通讯作者：
Hamajima N
中科院分区：
文献类型：
--
作者：
Senavong P;Yamamoto E;Keomoungkhoune P;Prasith N;Somoulay V;Kariya T;Saw YM;Pongvongsa T;Hamajima N
本研究旨在描述一家省级医院登革热住院患者的社会人口学和临床特征，并确定与重症登革热相关的因素。这是一项回顾性研究，涉及2018年1月至2019年4月期间在老挝人民民主共和国沙湾拿吉省医院住院的402名登革热患者。从患者记录中收集社会人口学因素、入院时的临床体征和实验室数据、最终诊断、入院前使用的卫生保健服务、入院日期和住院时间。雨季登革热住院患者人数高于旱季。在402例患者中，205例（51.0%）最终诊断为重症登革热。与≥15岁的成人相比，<15岁的儿童症状更多，严重登革热的比例更高（69.8%对35.9%），住院时间更长（3.5天对3.0天）。在多变量分析中，与严重登革热相关的因素是儿童入院时恶心（校正比值比=3.57，95%CI =1.05-12.09，P=0.04）和成人入院时持续呕吐（校正比值比=3.82，95%CI =1.23-11.92，P=0.02）。在成人中，与其他患者相比，最终诊断为严重登革热的患者入院时的肌酐水平显著较高。重症登革热的比例高于其他国家。入院时恶心和持续呕吐被认为是严重登革热的预测因素。为了减少老挝人民民主共和国严重登革热的发病率，需要改善获得医疗保健的机会、转诊系统和对医护人员的培训。
This study aimed to describe the socio-demographic and clinical characteristics of dengue inpatients at a provincial hospital, and to identify factors associated with severe dengue. This is a retrospective study involving 402 dengue patients admitted to the Savannakhet Provincial Hospital, Lao People’s Democratic Republic (Lao PDR), between January 2018 and April 2019. Socio-demographic factors, clinical signs and laboratory data on admission, final diagnosis, use of health care services before admission, admission date, and hospitalization period were collected from patient records. The number of dengue inpatients was higher in the rainy season than in the dry season. Of the 402 patients, 205 patients (51.0%) were finally diagnosed with severe dengue. Children aged <15 years had more symptoms, higher proportion of severe dengue (69.8% vs. 35.9%), and longer hospitalization (3.5 days vs. 3.0 days) than adults aged ≥15 years. In multivariable analyses, factors associated with severe dengue were nausea on admission (adjusted odds ratio=3.57, 95% CI=1.05–12.09, P=0.04) in children and persistent vomiting on admission (adjusted odds ratio=3.82, 95% CI=1.23–11.92, P=0.02) in adults. In adults, the creatinine level on admission was significantly higher in patients with a final diagnosis of severe dengue compared to the others. The proportion of severe dengue in our study was higher than that in other countries. Nausea and persistent vomiting on admission were suggested to be predictive factors for severe dengue. To reduce the incidence of severe dengue in Lao PDR, improvements in access to health care, referral system, and training of health care workers are needed.
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影响因子：
3.7
作者：
Pang, Junxiong;Thein, Tun-Linn;Lye, David C.
通讯作者：
Lye, David C.
影响因子：
0.9
作者：
Trinh Tien Dat;Kotani, Tomomi;Kikkawa, Fumitaka
通讯作者：
Kikkawa, Fumitaka
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3.8
作者：
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通讯作者：
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影响因子：
3.8
作者：
Carrasco, Luis R.;Leo, Yee Sin;Lye, David C.
通讯作者：
Lye, David C.
影响因子：
0.9
作者：
Louangpradith, Viengsakhone;Phoummalaysith, Bounfeng;Hamajima, Nobuyuki
通讯作者：
Hamajima, Nobuyuki