Nonredundant Rac-GEF control of actin cytoskeleton reorganization.
Nonredundant Rac-GEF control of actin cytoskeleton reorganization.
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DOI:
10.1016/j.tcb.2022.06.003
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发表时间:
2022-10
影响因子:
19
通讯作者:
Garcia-Mata, Rafael
中科院分区:
文献类型:
--
作者:
Kazanietz, Marcelo G.;Cooke, Mariana;Garcia-Mata, Rafael
Rac-GEFs operate in a non-redundant manner as downstream effectors of receptor tyrosine kinases to promote ruffle formation, indicative of unique modes of regulation and targeting. Current research is shedding light on the intricate signaling paradigms shaping spatiotemporal activation of the small GTPase Rac during the generation of actin-rich membrane protrusions.
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