Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.

Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.
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DOI:
10.1111/eci.12939
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发表时间:
2018-11
影响因子:
5.5
通讯作者:
Welch HCE
Welch HCE
中科院分区:
医学3区
文献类型:
--
作者:
Pantarelli C;Welch HCE

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Rac-GTP酶及其Rac-GEF激活剂在中性粒细胞的募集和宿主防御功能中发挥重要作用。这些蛋白质控制粘附分子的激活和细胞骨架动力学,使中性粒细胞的粘附,迁移和组织募集。它们还调节效应子功能,使中性粒细胞杀死细菌和真菌病原体,并清除碎片。本文就Rac‐ GTP酶和Rac‐GEFs在中性粒细胞粘附、迁移和募集中的作用作一综述。
Rac‐GTPases and their Rac‐GEF activators play important roles in the recruitment and host defence functions of neutrophils. These proteins control the activation of adhesion molecules and the cytoskeletal dynamics that enable the adhesion, migration and tissue recruitment of neutrophils. They also regulate the effector functions that allow neutrophils to kill bacterial and fungal pathogens, and to clear debris. This review focuses on the roles of Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment.
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