Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy.
Molecular mechanism of circadian rhythmicity of seizures in temporal lobe epilepsy.
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DOI：
10.3389/fncel.2012.00055
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发表时间：
2012
影响因子：
5.3
通讯作者：
Cho CH
中科院分区：
文献类型：
--
作者：
Cho CH
癫痫患者（PWE）癫痫发作的昼夜节律模式在两千年前首次被描述。然而，这些现象尚未得到足够的科学关注，可能是由于缺乏有希望的假设来解决癫痫发作和生理时钟之间的相互作用。为了在分子水平上提出可检验的假设，我们将回顾昼夜节律（尤其是控制时钟基因表达的转录因子）与 mTOR（雷帕霉素哺乳动物靶标）信号通路（癫痫的主要信号通路）之间的相互作用。然后，将提出两个密切相关的假设：（1）过度激活的mTOR信号分子的节律活性导致神经元兴奋性节律性增加。这些兴奋性的节律性增加周期性地超过癫痫阈值，显示出行为性癫痫发作。 (2) SCN神经元兴奋性的振荡通过长程投射通过下托调节海马的节律性兴奋性。将讨论已发表结果的发现、其影响以及新实验的建议。这些尝试可能会引发关于我们仍然需要了解自发性癫痫发作节律性的进一步讨论。
The circadian pattern of seizures in people with epilepsy (PWE) was first described two millennia ago. However, these phenomena have not received enough scientific attention, possibly due to the lack of promising hypotheses to address the interaction between seizure generation and a physiological clock. To propose testable hypotheses at the molecular level, interactions between circadian rhythm, especially transcription factors governing clock genes expression, and the mTOR (mammalian target of rapamycin) signaling pathway, the major signaling pathway in epilepsy, will be reviewed. Then, two closely related hypotheses will be proposed: (1) Rhythmic activity of hyperactivated mTOR signaling molecules results in rhythmic increases in neuronal excitability. These rhythmic increases in excitability periodically exceed the seizure threshold, displaying the behavioral seizures. (2) Oscillation of neuronal excitability in SCN modulates the rhythmic excitability in the hippocampus through subiculum via long-range projections. Findings from published results, their implications, and proposals for new experiments will be discussed. These attempts may ignite further discussion on what we still need to learn about the rhythmicity of spontaneous seizures.
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影响因子：
6.1
作者：
Arion, D;Sabatini, M;DeFelipe, J
通讯作者：
DeFelipe, J
影响因子：
5.6
作者：
Bazil, CW;Walczak, TS
通讯作者：
Walczak, TS
影响因子：
2.2
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
5.3
作者：
Abe, M;Herzog, ED;Block, GD
通讯作者：
Block, GD
影响因子：
14.5
作者：
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通讯作者：
Ramaekers, VT