Health Status, Persistent Symptoms, and Effort Intolerance One Year After Acute COVID-19 Infection.
Health Status, Persistent Symptoms, and Effort Intolerance One Year After Acute COVID-19 Infection.
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DOI：
10.1007/s11606-021-07379-z
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发表时间：
2022-04
影响因子：
5.7
通讯作者：
Goyal P
中科院分区：
文献类型：
--
作者：
Kingery JR;Safford MM;Martin P;Lau JD;Rajan M;Wehmeyer GT;Li HA;Alshak MN;Jabri A;Kofman A;Babu CS;Benitez EK;Palacardo F;Das IG;Kaylor K;Woo KM;Roberts NL;Rahiel S;Gali V;Han L;Lee J;Roszkowska N;Kim YE;Bakshi S;Hogan C;McNairy M;Pinheiro LC;Goyal P
急性COVID-19后遗症（PASC）的长期患病率和风险因素尚未得到很好的描述，可能对未接种疫苗的人群和政策制定者产生重要影响。评估COVID-19感染后约1年的健康状况、持续症状和努力耐受性使用调查和临床数据的回顾性观察性队列研究调查受访者是2020年3月3日至5月15日期间需要急诊科就诊或住院的急性COVID-19感染幸存者。自我报告的健康状况、持续症状和努力耐受性530名受访者（住院和调查之间的中位时间为332天[IQR 325-344]）的平均年龄为59. 2 ± 16. 3岁，44. 5%为女性，70. 8%为非白人。其中，41.5%的人报告说健康状况比一年前更差，44.2%的人报告说症状持续存在，36.2%的人报告说搬运/搬运杂货受限，35.5%的人报告说爬一段楼梯受限，38.1%的人报告说弯曲/跪/弯腰受限，22.1%的人报告说行走一个街区受限。即使那些没有高风险共病的人和那些只在急诊室（但不住院）看到的人也经历了健康状况的显著恶化，持续的症状和努力耐受性的限制。女性（调整后的相对风险比[aRRR] 1.26，95% CI 1.01-1.56）、需要机械通气的患者（aRRR 1.48，1.02-2.14）和HIV感染者（aRRR 1.75，1.14-2.69）更有可能报告持续症状。年龄和其他更严重COVID-19疾病的风险因素与PASC风险增加无关。PASC可能在COVID-19后1年非常常见，这些症状严重到足以影响患者的日常运动耐量。PASC症状分布广泛，不限于一个特定的患者群体，并且似乎与年龄无关。这些数据对疫苗犹豫不决的个人、政策制定者和医生管理COVID-19大流行的新出现的长期但未知的影响具有影响。在线版本包含补充材料，可通过10.1007/s11606-021-07379-z获得。
The long-term prevalence and risk factors for post-acute COVID-19 sequelae (PASC) are not well described and may have important implications for unvaccinated populations and policy makers. To assess health status, persistent symptoms, and effort tolerance approximately 1 year after COVID-19 infection Retrospective observational cohort study using surveys and clinical data Survey respondents who were survivors of acute COVID-19 infection requiring Emergency Department presentation or hospitalization between March 3 and May 15, 2020. Self-reported health status, persistent symptoms, and effort tolerance The 530 respondents (median time between hospital presentation and survey 332 days [IQR 325–344]) had mean age 59.2±16.3 years, 44.5% were female and 70.8% were non-White. Of these, 41.5% reported worse health compared to a year prior, 44.2% reported persistent symptoms, 36.2% reported limitations in lifting/carrying groceries, 35.5% reported limitations climbing one flight of stairs, 38.1% reported limitations bending/kneeling/stooping, and 22.1% reported limitations walking one block. Even those without high-risk comorbid conditions and those seen only in the Emergency Department (but not hospitalized) experienced significant deterioration in health, persistent symptoms, and limitations in effort tolerance. Women (adjusted relative risk ratio [aRRR] 1.26, 95% CI 1.01–1.56), those requiring mechanical ventilation (aRRR 1.48, 1.02–2.14), and people with HIV (aRRR 1.75, 1.14–2.69) were significantly more likely to report persistent symptoms. Age and other risk factors for more severe COVID-19 illness were not associated with increased risk of PASC. PASC may be extraordinarily common 1 year after COVID-19, and these symptoms are sufficiently severe to impact the daily exercise tolerance of patients. PASC symptoms are broadly distributed, are not limited to one specific patient group, and appear to be unrelated to age. These data have implications for vaccine hesitant individuals, policy makers, and physicians managing the emerging longer-term yet unknown impact of the COVID-19 pandemic. The online version contains supplementary material available at 10.1007/s11606-021-07379-z.
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影响因子：
7.8
作者：
Amodio E;Capra G;Casuccio A;Grazia S;Genovese D;Pizzo S;Calamusa G;Ferraro D;Giammanco GM;Vitale F;Bonura F
通讯作者：
Bonura F
DOI：
10.1056/nejmoa2022926
发表时间：
2020-11-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
RECOVERY Collaborative Group;Horby P;Mafham M;Linsell L;Bell JL;Staplin N;Emberson JR;Wiselka M;Ustianowski A;Elmahi E;Prudon B;Whitehouse T;Felton T;Williams J;Faccenda J;Underwood J;Baillie JK;Chappell LC;Faust SN;Jaki T;Jeffery K;Lim WS;Montgomery A;Rowan K;Tarning J;Watson JA;White NJ;Juszczak E;Haynes R;Landray MJ
通讯作者：
Landray MJ
影响因子：
13.8
作者：
Nasserie T;Hittle M;Goodman SN
通讯作者：
Goodman SN
影响因子：
158.5
作者：
Sterling, TR;Vlahov, D;Quinn, TC
通讯作者：
Quinn, TC
DOI：
10.1016/s1473-3099(10)70049-9
发表时间：
2010-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Klein SL;Jedlicka A;Pekosz A
通讯作者：
Pekosz A