Cajal, Retzius, and Cajal-Retzius cells.
Cajal, Retzius, and Cajal-Retzius cells.
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DOI：
10.3389/fnana.2014.00048
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发表时间：
2014
影响因子：
2.9
通讯作者：
Noctor SC
中科院分区：
文献类型：
--
作者：
Martínez-Cerdeño V;Noctor SC
出生前大脑皮层的边缘区（MZ）在发育中的新皮层中的细胞迁移和层状图案中起着至关重要的作用，并且其在成人脑中的等同物-第I层，参与成人新皮层内的皮层回路整合。MZ/层I，也被称为Meynert的丛状层和细胞贫乏区，是包括神经胶质细胞、神经元和Cajal-Retzius（CR）细胞在内的几种细胞群的家园。Cajal曾经说过，MZ是系统发育系列中最古老的地层之一，人类的第I层特征与除鱼类之外的所有脊椎动物相似。尽管CR细胞存在于所有发育和成年脊椎动物脑的MZ/I层中，并且经过一百多年的研究，I层细胞的表型和功能仍然没有明确定义。最近的技术进步在功能和发育研究方面取得了重大进展，但MZ/第I层神经元仍有许多需要了解的地方。自Retzius和Cajal的时代以来，以及Marín-Padilla等人的现代研究，CR细胞的研究一直基于它们在高尔基体染色中的形态特征。然而，自Cajal的最初描述以来，术语“CR细胞”已被不同地应用，并且现在通常用于指示MZ/层I中的reelin（Reln）阳性细胞。在这里，我们回顾了卡哈尔，Retzius和其他有关CR细胞的工作历史。我们将建立由Cajal，Retzius和其他人的CR细胞形态的原始描述之间的联系，和目前的理解，驻留在MZ/层I的细胞群的基础上使用的细胞标记物。我们建议使用术语“CR细胞”的类神经元，表达Reln在MZ/层I在产前，发育和成人大脑皮层。
The marginal zone (MZ) of the prenatal cerebral cortex plays a crucial role in cellular migration and laminar patterning in the developing neocortex and its equivalent in the adult brain – layer I, participates in cortical circuitry integration within the adult neocortex. The MZ/layer I, which has also been called the plexiform layer and cell-poor zone of Meynert, among others, is home to several cell populations including glia, neurons, and Cajal–Retzius (CR) cells. Cajal once said that the MZ is one of the oldest formations in the phylogenetic series, and that the characteristics of layer I in human are similar in all vertebrates except fish. Despite the presence of CR cells in the MZ/layer I of all developing and adult vertebrate brains, and more than one hundred years of research, the phenotype and function of layer I cells have still not been clearly defined. Recent technological advances have yielded significant progress in functional and developmental studies, but much remains to be understood about neurons in MZ/layer I. Since the time of Retzius and Cajal, and continuing with modern era research from the likes of Marín-Padilla, the study of CR cells has been based on their morphological characteristics in Golgi staining. However, since Cajal’s initial description, the term “CR cell” has been applied differently and now is often used to indicate reelin (Reln)-positive cells in MZ/layer I. Here we review the history of work by Cajal, Retzius, and others pertaining to CR cells. We will establish a link between original descriptions of CR cell morphology by Cajal, Retzius, and others, and current understandings of the cell populations that reside in MZ/layer I based on the use of cellular markers. We propose to use the term “CR cell” for the class of neurons that express Reln in the MZ/layer I in both prenatal, developing and adult cerebral cortex.
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影响因子：
16.2
作者：
Hevner, RF;Shi, LM;Rubenstein, JLR
通讯作者：
Rubenstein, JLR
影响因子：
2.9
作者：
Chowdhury TG;Jimenez JC;Bomar JM;Cruz-Martin A;Cantle JP;Portera-Cailliau C
通讯作者：
Portera-Cailliau C
影响因子：
4.7
作者：
Cosgrove KE;Maccaferri G
通讯作者：
Maccaferri G
影响因子：
3.7
作者：
Abraham, H;Pérez-García, CG;Meyer, G
通讯作者：
Meyer, G
影响因子：
3.7
作者：
Abellan, Antonio;Menuet, Arnaud;Retaux, Sylvie
通讯作者：
Retaux, Sylvie