Atrial fibrillation increases inpatient and 4-year all-cause mortality in critically ill patients with liver cirrhosis.
Atrial fibrillation increases inpatient and 4-year all-cause mortality in critically ill patients with liver cirrhosis.
复制标题
心房颤动会增加肝硬化危重患者的住院死亡率和 4 年全因死亡率
DOI：
10.21037/atm-21-3111
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发表时间：
2021-08
影响因子：
--
通讯作者：
Chong Y
中科院分区：
文献类型：
--
作者：
Luo Y;Wu B;Wu Y;Peng L;Li Z;Zhu J;Su Z;Liu J;Li S;Chong Y
背景心房颤动（AF）和肝硬化之间的关系尚不清楚。因此，本研究的目的是使用大型数据库确定AF与肝硬化重症患者短期和4年死亡率之间的相关性。方法使用重症监护医学信息市场III（MIMIC III）数据库识别2001年至2012年在重症监护室住院的肝硬化患者。从数据库中提取人口统计学和临床数据。我们收集了研究中每例患者的临床数据和人口统计学信息。Kaplan-Meier分析和多变量考克斯回归模型分析房颤与住院和4年全因死亡率之间的关系。结果共纳入1,481例肝硬化患者，平均年龄58岁，男性68%，房颤患病率为14.18%。住院患者的全因死亡率为26.6%，住院死亡患者中AF的发生率显著高于其他患者（21.57% vs.11.50%，P<0.001）。多变量考克斯回归分析表明，房颤与住院患者全因死亡率[风险比（HR）：1.52，95%置信区间（CI）：1.19-1.95，P<0.001]和4年全因死亡率（HR：1.55，95% CI：1.12-2.13，P=0.008）显著相关。Kaplan-Meier生存分析显示，AF患者的住院和4年全因死亡率显著较高。结论肝硬化危重症患者房颤发生率高，房颤的存在是导致住院和4年全因死亡的独立危险因素。
Background The association between atrial fibrillation (AF) and cirrhosis is unclear. Therefore, the aim of the present study was to determine the association between AF and short-term and 4-year mortality in critically ill patients with cirrhosis using a large database. Methods The Medical Information Mart for Intensive Care III (MIMIC III) database was used to identify patients with cirrhosis hospitalized in an intensive care unit from 2001 to 2012. Demographic and clinical data were extracted from the database. Clinical data and demographic information were collected for each patient in our study. Kaplan-Meier analysis and multivariate Cox regression models were performed to examine the relation between atrial fibrillation and in-hospital and 4-year all-cause mortality. Results A total of 1,481 patients (mean age: 58 years, 68% male) with liver cirrhosis were included in the analysis, and the prevalence of AF was 14.18%. The inpatient all-cause mortality rate was 26.6%, and patients who died in hospital had a significantly higher rate of AF (21.57% vs. 11.50%, P<0.001). Multivariate Cox regression analysis indicated that AF was significantly associated with inpatient all-cause mortality [hazard ratio (HR): 1.52, 95% confidence interval (CI): 1.19–1.95, P<0.001], and 4-year all-cause mortality (HR: 1.55, 95% CI: 1.12–2.13, P=0.008). Kaplan-Meier survival analysis showed that patients with AF had a significantly higher inpatient and 4-year all-cause mortality. Conclusions Critically ill patients with liver cirrhosis have a high rate of AF, and the presence of AF is an independent risk factor for inpatient and 4-year all-cause mortality.
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影响因子：
2.4
作者：
Kang MK;Park JG;Kim MC
通讯作者：
Kim MC
影响因子：
8.8
作者：
Saeed M;Villarroel M;Reisner AT;Clifford G;Lehman LW;Moody G;Heldt T;Kyaw TH;Moody B;Mark RG
通讯作者：
Mark RG
影响因子：
8.8
作者：
Vincent, JL;de Mendonca, A;Blecher, S
通讯作者：
Blecher, S
影响因子：
3.9
作者：
Bernardi, Mauro;Maggioli, Caterina;Zaccherini, Giacomo
通讯作者：
Zaccherini, Giacomo
DOI：
10.5114/aic.2017.70198
发表时间：
2017
期刊：
Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
影响因子：
--
作者：
Zhou Y;Lai C;Peng C;Chen M;Li B;Wang X;Sun J;Sun C
通讯作者：
Sun C