Host genetics of Epstein-Barr virus infection, latency and disease.
Host genetics of Epstein-Barr virus infection, latency and disease.
复制标题
DOI：
10.1002/rmv.1816
复制
发表时间：
2015-03
影响因子：
11.1
通讯作者：
Kellam, Paul
中科院分区：
文献类型：
--
作者：
Houldcroft, Charlotte J.;Kellam, Paul
EB 病毒 (EBV) 感染 95% 的成年人，是传染性单核细胞增多症的病因。它还与全球 1% 的癌症有关，例如鼻咽癌、霍奇金淋巴瘤和伯基特淋巴瘤。人类和癌症遗传学研究现在是确定与许多癌症相关的基因变异的主要力量，包括鼻咽癌和霍奇金淋巴瘤。宿主遗传学在传染病中也很重要。然而，目前还没有大规模的努力来了解人类遗传变异在原发性 EBV 感染和潜伏期中所起的作用。这篇综述涵盖了 25 年来对宿主对 EBV 感染和疾病的遗传易感性的研究，从候选基因研究，到第一个 EBV 抗体反应的全基因组关联研究，以及霍奇金淋巴瘤的 EBV 状态分层全基因组关联研究。尽管许多基因与 EB 病毒相关疾病有关，但研究通常规模较小，无法在不同疾病中进行重复或随访。需要更大规模、适当的基因组研究来了解宿主对 EBV 的反应，从而使我们对 EBV 感染生物学的理解超越目前已识别的少数基因。自发现 EBV 并将其鉴定为人类致癌病毒五十年后，首次全基因组和全外显子组研究揭示了未来的一瞥，揭示了宿主与 EBV 相互作用的核心新人类基因。 © 2014 作者。 John Wiley & Sons Ltd 出版的《医学病毒学评论》
Epstein–Barr virus (EBV) infects 95% of the adult population and is the cause of infectious mononucleosis. It is also associated with 1% of cancers worldwide, such as nasopharyngeal carcinoma, Hodgkin's lymphoma and Burkitt's lymphoma. Human and cancer genetic studies are now major forces determining gene variants associated with many cancers, including nasopharyngeal carcinoma and Hodgkin's lymphoma. Host genetics is also important in infectious disease; however, there have been no large-scale efforts towards understanding the contribution that human genetic variation plays in primary EBV infection and latency. This review covers 25 years of studies into host genetic susceptibility to EBV infection and disease, from candidate gene studies, to the first genome-wide association study of EBV antibody response, and an EBV-status stratified genome-wide association study of Hodgkin's lymphoma. Although many genes are implicated in EBV-related disease, studies are often small, not replicated or followed up in a different disease. Larger, appropriately powered genomic studies to understand the host response to EBV will be needed to move our understanding of the biology of EBV infection beyond the handful of genes currently identified. Fifty years since the discovery of EBV and its identification as a human oncogenic virus, a glimpse of the future is shown by the first whole-genome and whole-exome studies, revealing new human genes at the heart of the host–EBV interaction. © 2014 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.
登录
查看更多内容
影响因子：
2.6
作者：
Diamantopoulos, Panagiotis T.;Kalotychou, Vassiliki;Viniou, Nora-Athina
通讯作者：
Viniou, Nora-Athina
影响因子：
8.8
作者：
Caillard, S.;Lamy, F. X.;Moulin, B.
通讯作者：
Moulin, B.
影响因子：
5.4
作者：
Durovic, Bojana;Gasser, Olivier;Hess, Christoph
通讯作者：
Hess, Christoph
影响因子：
14.9
作者：
Franceschini A;Szklarczyk D;Frankild S;Kuhn M;Simonovic M;Roth A;Lin J;Minguez P;Bork P;von Mering C;Jensen LJ
通讯作者：
Jensen LJ
影响因子：
4.2
作者：
Fan Q;He JF;Wang QR;Cai HB;Sun XG;Zhou XX;Qin HD;Shugart YY;Jia WH
通讯作者：
Jia WH