Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis.
Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis.
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DOI：
10.1186/1880-6805-33-37
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发表时间：
2014-12-20
影响因子：
3.1
通讯作者：
Takashima Y
中科院分区：
文献类型：
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作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Saga N;Ohtsu I;Hoshino H;Takashima Y
线粒体DNA 5178胞嘧啶/腺嘌呤（Mt5178 C/A）多态性据报道调节咖啡消费对高血压，血脂异常和糖耐量异常风险的影响。本分析的目的是调查Mt5178 C/A多态性是否改变了日本男性健康检查受试者饮用咖啡对红细胞参数的影响。从定期到医院进行体检的个人中选择了总共436名男性（平均年龄±标准差，54.1 ± 7.8岁）。在Mt5178 C/A基因分型后，进行了一项探索性横断面分析，评估Mt5178 C/A多态性和咖啡摄入对红细胞计数、红细胞压积和血红蛋白的联合影响。对于Mt5178 C基因型男性，在调整年龄、体重指数、饮酒量、习惯性吸烟和绿色茶摄入量后，咖啡摄入量显著降低了红细胞计数（趋势P = 0.022）和血红蛋白（趋势P = 0.035）。贫血的风险，定义为血红蛋白<14 g/dL，在上述调整后，似乎取决于咖啡的摄入量（趋势P = 0.078），每天饮用≥4杯咖啡的男性的贫血校正比值比显著高于每天饮用<1杯咖啡的男性（比值比= 3.771，95%置信区间：1.088至13.06，P = 0.036）。对于Mt5178 A基因型男性，咖啡消费可能降低贫血的风险（趋势P = 0.049）。然而，经过上述调整后，统计学显著性消失（趋势P = 0.137）。这种探索性的横断面分析表明，Mt5178 C/A多态性调节咖啡消费对红细胞参数的影响，并在男性日本健康检查受试者贫血的风险。
Mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees. A total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted. For Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137). This exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees.
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影响因子：
2.8
作者：
Ito T;Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Hoshino H;Takashima Y
通讯作者：
Takashima Y
DOI：
10.1186/1477-5751-12-17
发表时间：
2013-11-20
期刊：
Journal of negative results in biomedicine
影响因子：
--
作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Hoshino H;Takashima Y
通讯作者：
Takashima Y
影响因子：
3.1
作者：
Nishimura T;Motoi M;Niri Y;Hoshi Y;Kondo R;Watanuki S
通讯作者：
Watanuki S
DOI：
10.3109/09637486.2011.566848
发表时间：
2011-09-01
影响因子：
3.9
作者：
Ahmed, Faruk;Al-Sumaie, Mona A.
通讯作者：
Al-Sumaie, Mona A.
影响因子：
4.5
作者：
MEHTA, SW;PRITCHARD, ME;STEGMAN, C
通讯作者：
STEGMAN, C