The control of food intake: behavioral versus molecular perspectives.

The control of food intake: behavioral versus molecular perspectives.
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DOI:
10.1016/j.cmet.2009.04.007
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发表时间:
2009-06
期刊:
影响因子:
29
通讯作者:
Woods SC
Woods SC
中科院分区:
生物学1区
文献类型:
--
作者:
Woods SC

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为了满足对能量的持续需求,生物体使用不同的信号来匹配食物摄入和能量需求。本文回顾了饱足感信号和肥胖信号对食物摄入的影响,包括它们如何在大脑中相互作用以及它们的影响如何随着经验而变化。进餐开始受到外部环境因素的影响,而进餐量则受到一系列信号的影响,这些信号可以根据指示食物热量含量的可靠性进行划分。有人认为,饱腹感信号的可塑性使其不适合作为控制体重的药理学目标。
To meet the continuous demand for energy, organisms use diverse signals to match food intake with energy needs. This paper reviews the effect of satiation signals and adiposity signals on food intake, including how they interact in the brain and how their influence changes with experience. Whereas meal initiation is influenced by external environmental factors, meal size is influenced by an array of signals that can be partitioned according to their reliability in indicating caloric content of food. It is argued that the malleability of satiation signals renders them poor candidates as pharmacological targets to control body weight.
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