Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt
Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt
复制标题
肌管蛋白相关蛋白 14 通过抑制 Akt 抑制心肌肥厚
DOI：
10.1038/s41419-020-2330-6
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发表时间：
2020-02
影响因子：
9
通讯作者：
Zhang Yan-Zhou
中科院分区：
文献类型：
--
作者：
Zhang Jie-Lei;Zhang Dian-Hong;Li Ya-Peng;Wu Lei-Ming;Liang Cui;Yao Rui;Wang Zheng;Feng Sheng-dong;Wang Zhong-Min;Zhang Yan-Zhou
心脏肥大（CH）是许多心血管疾病的独立危险因素，也是老年人发病和死亡的主要原因之一。病理性CH涉及过度的蛋白质合成，心肌细胞体积增加，并最终发展为心力衰竭。肌管蛋白相关蛋白14（MTMR14）是肌管蛋白（MTM）相关蛋白家族的成员，其参与细胞凋亡、衰老、炎症和自噬。然而，其在CH中的确切功能仍不清楚。在此，我们研究了MTMR14在CH中的作用。我们发现，MTMR14的表达在肥大小鼠心脏中增加。心脏MTMR14缺陷的小鼠表现出加重的AB诱导的CH表型。与此相反，MTMR14过表达防止压力超负荷诱导的肥大。在分子水平上，在MTMR14缺乏的情况下预防CH涉及Akt通路组分的升高，Akt通路组分是调节细胞凋亡和细胞增殖的关键因素。这些结果表明MTMR14是治疗CH的新分子靶标。
Cardiac hypertrophy (CH) is an independent risk factor for many cardiovascular diseases, and is one of the primary causes of morbidity and mortality in elderly people. Pathological CH involves excessive protein synthesis, increased cardiomyocyte size, and ultimately the development of heart failure. Myotubularin-related protein 14 (MTMR14) is a member of the myotubularin (MTM)-related protein family, which is involved in apoptosis, aging, inflammation, and autophagy. However, its exact function in CH is still unclear. Herein, we investigated the roles of MTMR14 in CH. We show that MTMR14 expression was increased in hypertrophic mouse hearts. Mice deficient in heart MTMR14 exhibited an aggravated aortic-banding (AB)-induced CH phenotype. In contrast, MTMR14 overexpression prevented pressure overload-induced hypertrophy. At the molecular level, prevention of CH in the absence of MTMR14 involved elevations in Akt pathway components, which are key elements that regulate apoptosis and cell proliferation. These results demonstrate that MTMR14 is a new molecular target for the treatment of CH.
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影响因子：
3.5
作者：
Li, Zhaodong;Rong, Li;Li, Xiang
通讯作者：
Li, Xiang
影响因子：
8.9
作者：
M. Milan;G. Rovere;M. Smits;S. Ferraresso;P. Pastore;M. Marin;S. Bogialli;T. Patarnello;L. Bargelloni;V. Matozzo
通讯作者：
M. Milan;G. Rovere;M. Smits;S. Ferraresso;P. Pastore;M. Marin;S. Bogialli;T. Patarnello;L. Bargelloni;V. Matozzo
DOI：
--
发表时间：
2003
期刊：
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
影响因子：
--
作者：
R. Artenie;A. Artenie;D. Ungureanu;I. Haulica;A. Coşovanu
通讯作者：
R. Artenie;A. Artenie;D. Ungureanu;I. Haulica;A. Coşovanu
影响因子：
3.5
作者：
Li, Jing;Yuan, Yu-Pei;Tang, Qi-Zhu
通讯作者：
Tang, Qi-Zhu
影响因子：
3.6
作者：
Gomez I;Duval V;Silvestre JS
通讯作者：
Silvestre JS