Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease.

Reprogramming therapeutics: iPS cell prospects for neurodegenerative disease.
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DOI:
10.1016/j.neuron.2009.01.024
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发表时间:
2009-02-12
期刊:
影响因子:
16.2
通讯作者:
Doege, Claudia A.
Doege, Claudia A.
中科院分区:
医学1区
文献类型:
--
作者:
Abeliovich, Asa;Doege, Claudia A.

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最近描述的体细胞重编程为胚胎干(ES)细胞样表型,称为诱导多能干(iPS)细胞技术,Dimos等和Ebert等的两项最新研究描述了神经退行性疾病患者来源的iPS细胞培养物的初步表征,作为神经退行性疾病的证据。这一技术的实用性。
The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like phenotype, termed induced pluripotent stem (iPS) cell technology, presents an exciting potential venue towards cell-based therapeutics and disease models for neurodegenerative disorders Two recent studies from Dimos et al. and Ebert et al. describe the initial characterization of neurodegenerative disease patient-derived iPS cell cultures as proof-of-concept for the utility of this technology.
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