Ockham's razor and the metabolic syndrome.
Ockham's razor and the metabolic syndrome.
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DOI：
10.1016/j.soard.2021.04.004
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发表时间：
2021-07
影响因子：
3.1
通讯作者：
Dohm, G. Lynis
中科院分区：
文献类型：
--
作者：
Pories, Walter J.;Jones, Terry E.;Houmard, Joseph A.;DeMaria, Eric;Dohm, G. Lynis
减肥/代谢手术对几乎每个组织和器官系统的广泛影响仍未得到解释。体重减轻虽然是一个主要因素，但并不能完全解释2型糖尿病迅速、完全和持久的缓解、胰岛功能的恢复、癌症患病率的降低、大脑灰质的增加和全因死亡率的下降。这篇综述支持代谢综合征不是一组单独的疾病，而是碳水化合物和脂类利用的共同缺陷的多重表达的论点。这一错误很可能是由食物刺激的前肠代谢异常信号引起的，该信号限制了2-碳片段进入三羧酸循环，乳酸的积累，进而增加了葡萄糖和胰岛素。外科手术通过减少食物和前肠粘膜之间的接触来限制这种信号。该信号的物种形成(S)可能为药物开发提供一条新的途径。
The broad effects of bariatric/metabolic surgery on virtually every tissue and organ system remain unexplained. Weight loss, although a major factor, does not fully account for the rapid, full, and durable remission of type 2 diabetes, return of islet function, reduction of the prevalence of cancers, increase in gray matter of the brain, and decrease in all-cause mortality. This review supports the thesis that the metabolic syndrome is not a group of separate diseases but rather multiple expressions of a shared defect in the utilization of carbohydrates and lipids. That error is probably caused by a dysmetabolic signal from the foregut, stimulated by food, that limits entry of 2-carbon fragments into the tricarboxylic acid cycle, the accumulation of lactate and, in turn, increases in glucose and insulin. Surgery limits that signal by reducing contact between food and foregut mucosa. Speciation of that signal(s) may offer a new pathway for drug development.
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影响因子：
9
作者：
Christou, NV;Sampalis, JS;MacLean, LD
通讯作者：
MacLean, LD
影响因子：
16.9
作者：
Courcoulas, Anita P.;King, Wendy C.;Yanovski, Susan Z.
通讯作者：
Yanovski, Susan Z.
糖尿病和非糖尿病肥胖患者的肌肉和脂肪组织形态，胰岛素敏感性和β细胞功能：减肥手术的影响。
影响因子：
4.6
作者：
Camastra S;Vitali A;Anselmino M;Gastaldelli A;Bellini R;Berta R;Severi I;Baldi S;Astiarraga B;Barbatelli G;Cinti S;Ferrannini E
通讯作者：
Ferrannini E
影响因子：
5.6
作者：
Juraschek, Stephen P.;Selvin, Elizabeth;Young, J. Hunter
通讯作者：
Young, J. Hunter
影响因子：
7.7
作者：
Crawford SO;Hoogeveen RC;Brancati FL;Astor BC;Ballantyne CM;Schmidt MI;Young JH
通讯作者：
Young JH