Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study.
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DOI：
10.1093/ije/dyq126
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发表时间：
2010-12
影响因子：
7.7
通讯作者：
Young JH
中科院分区：
文献类型：
--
作者：
Crawford SO;Hoogeveen RC;Brancati FL;Astor BC;Ballantyne CM;Schmidt MI;Young JH
背景越来越多的证据表明，氧化能力不足与2型糖尿病的发生有关。这一概念尚未在大规模的、基于人群的研究中得到很好的检验。方法为了验证这一假设，我们评估了1709名未服用二甲双胍的老年人中血浆乳酸（氧化能力和能量消耗之间差距的指标）与2型糖尿病的横断面相关性，这些老年人参与了社区动脉粥样硬化风险（ARIC）颈动脉MRI研究。结果2型糖尿病的患病率在乳酸四分位数之间呈上升趋势（11、14、20和30%; P <0.0001）。调整人口统计学因素、体力活动、体重指数和腰围后，乳酸四分位数中2型糖尿病的相对比值分别为0.98 [95%置信区间（CI）0.59-1.64]、1.64（95% CI 1.03-2.64）和2.23（95% CI 1.38-3.59）。此外，在非糖尿病成人中，乳酸盐与较高的空腹血糖相关。结论血浆乳酸与老年人2型糖尿病密切相关。在氧化能力和糖尿病风险的研究中，血浆乳酸盐值得更多的关注。
Background Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies. Methods To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. Results The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59–1.64], 1.64 (95% CI 1.03–2.64) and 2.23 (95% CI 1.38–3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults. Conclusions Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
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影响因子：
15.9
作者：
CONSOLI, A;NURJHAN, N;GERICH, JE
通讯作者：
GERICH, JE
影响因子：
7.1
作者：
KELLEY, DE;SLASKY, BS;JANOSKY, J
通讯作者：
JANOSKY, J
影响因子：
9.8
作者：
DOAR, JWH;WYNN, V;CRAMP, DG
通讯作者：
CRAMP, DG
影响因子：
9.8
作者：
LOVEJOY, J;NEWBY, FD;DIGIROLAMO, M
通讯作者：
DIGIROLAMO, M
影响因子：
4.8
作者：
DIGIROLAMO, M;NEWBY, FD;LOVEJOY, J
通讯作者：
LOVEJOY, J