The enigmatic origin of bovine mtDNA haplogroup R: sporadic interbreeding or an independent event of Bos primigenius domestication in Italy?
The enigmatic origin of bovine mtDNA haplogroup R: sporadic interbreeding or an independent event of Bos primigenius domestication in Italy?
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DOI：
10.1371/journal.pone.0015760
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发表时间：
2010-12-28
期刊：
影响因子：
3.7
通讯作者：
Ferretti L
中科院分区：
文献类型：
--
作者：
Bonfiglio S;Achilli A;Olivieri A;Negrini R;Colli L;Liotta L;Ajmone-Marsan P;Torroni A;Ferretti L
当家养牛从肥沃的新月会扩散出来时，当地的野生牛(Bos Primienius)仍然很多。此外，奥罗什牛和引进牛往往共存了数千年，因此不仅为自然杂交提供了潜在的条件，也为牧民建立涉及当地奥罗什种群的二级驯化中心提供了潜在的条件。最近的线粒体基因组分析表明，并不是所有的现代牛磺酸mtDNA都属于起源于近东的浅层大单倍群T，正如在牛的系统发育中发现的T节点之前辐射的三个分支(P、Q和R)所证明的那样。这些不常见的单倍群是评估是否发生零星杂交或甚至发生额外的牛驯化事件的极好工具。对37个欧洲品种的1,747个牛样本(1,128个新样本和619个以前研究的样本)的线粒体DNA(MtDNA)控制区变异的调查发现，16个新的非T线粒体DNA被确认为单倍群Q和R的成员。这些线粒体DNA然后被整合到包含所有可用的P、Q和R完整线粒体DNA序列的系统发育树中。对单倍群P(N = 2)、Q(N = 16)和R(N = 10)的28个线粒体基因组的系统发育分析，以及对所有已发表的线粒体DNA数据集的广泛调查，揭示了单倍群Q和T之间的主要相似性。因此，Q很可能代表了与T亚群的创建者一起在近东驯化的另一个次要谱系。然而，单倍群R至少目前只在意大利被发现，而在其他地方，无论是现代的还是古代的样品中都没有发现，因此支持了一个来自欧洲奥罗什的起源。单倍群R可能是通过野生动物和家畜的零星杂交获得的，但我们的数据不排除在意大利发生局部和次要事件的可能性。
When domestic taurine cattle diffused from the Fertile Crescent, local wild aurochsen (Bos primigenius) were still numerous. Moreover, aurochsen and introduced cattle often coexisted for millennia, thus providing potential conditions not only for spontaneous interbreeding, but also for pastoralists to create secondary domestication centers involving local aurochs populations. Recent mitochondrial genomes analyses revealed that not all modern taurine mtDNAs belong to the shallow macro-haplogroup T of Near Eastern origin, as demonstrated by the detection of three branches (P, Q and R) radiating prior to the T node in the bovine phylogeny. These uncommon haplogroups represent excellent tools to evaluate if sporadic interbreeding or even additional events of cattle domestication occurred. The survey of the mitochondrial DNA (mtDNA) control-region variation of 1,747 bovine samples (1,128 new and 619 from previous studies) belonging to 37 European breeds allowed the identification of 16 novel non-T mtDNAs, which after complete genome sequencing were confirmed as members of haplogroups Q and R. These mtDNAs were then integrated in a phylogenetic tree encompassing all available P, Q and R complete mtDNA sequences. Phylogenetic analyses of 28 mitochondrial genomes belonging to haplogroups P (N = 2), Q (N = 16) and R (N = 10) together with an extensive survey of all previously published mtDNA datasets revealed major similarities between haplogroups Q and T. Therefore, Q most likely represents an additional minor lineage domesticated in the Near East together with the founders of the T subhaplogroups. Whereas, haplogroup R is found, at least for the moment, only in Italy and nowhere else, either in modern or ancient samples, thus supporting an origin from European aurochsen. Haplogroup R could have been acquired through sporadic interbreeding of wild and domestic animals, but our data do not rule out the possibility of a local and secondary event of B. primigenius domestication in Italy.
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DOI：
10.1073/pnas.0509210103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Beja-Pereira, Albano;Caramelli, David;Bertorelle, Giorgio
通讯作者：
Bertorelle, Giorgio
影响因子：
56.9
作者：
Hanotte, O;Bradley, DG;Rege, JEO
通讯作者：
Rege, JEO
影响因子：
3.7
作者：
Ajmone-Marsan, Paolo;Garcia, Jose Fernando;Lenstra, Johannes A.
通讯作者：
Lenstra, Johannes A.
影响因子：
3.7
作者：
Edwards CJ;Magee DA;Park SD;McGettigan PA;Lohan AJ;Murphy A;Finlay EK;Shapiro B;Chamberlain AT;Richards MB;Bradley DG;Loftus BJ;MacHugh DE
通讯作者：
MacHugh DE
影响因子：
4.1
作者：
Lai, SJ;Liu, YP;Yao, YG
通讯作者：
Yao, YG