Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Correlation with psychosis and response to neuroleptic treatment.
Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients. Correlation with psychosis and response to neuroleptic treatment.
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精神分裂症患者血浆高香草酸水平的纵向测量。
DOI：
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发表时间：
1986
影响因子：
--
通讯作者：
Steven M. Paul
中科院分区：
文献类型：
--
作者：
D. Pickar;R. Labarca;A. Doran;Owen M. Wolkowitz;Alec Roy;Alan Breier;Markku Linnoila;Steven M. Paul
在精神分裂症患者中，在双盲安慰剂对照的抗精神病药治疗（N = 16）和戒断（N = 11）的5周期间，测定了高香草酸（HVA）（一种主要的循环多巴胺（DA）代谢物）的血浆水平。抗精神病药物治疗和停药均与HVA血浆水平的时间依赖性变化相关;治疗与降低相关，停药与增加相关。在这两种情况下纵向测量的血浆HVA水平与精神病等级高度相关。此外，个体平均每周血浆HVA水平的变化可预测治疗反应，包括精神分裂症阳性和阴性症状的变化。这些数据是一致的建议，抗精神病药物的作用机制涉及，除了短期DA受体阻滞剂，突触前DA活性的缓慢发展下降。
The plasma levels of homovanillic acid (HVA), a major circulating dopamine (DA) metabolite, were measured in schizophrenic patients during five weeks each of double-blind placebo-controlled neuroleptic treatment (N = 16) and withdrawal (N = 11). Both neuroleptic treatment and withdrawal were associated with time-dependent changes in the plasma levels of HVA; treatment was associated with decreases and withdrawal with increases. The levels of plasma HVA measured longitudinally during both conditions were highly correlated with psychosis ratings. Moreover, changes in individual mean weekly levels of plasma HVA were predictive of treatment response, including changes in both positive and negative symptoms of schizophrenia. These data are consistent with the suggestion that the mechanisms of action of antipsychotic drugs involve, in addition to short-term DA receptor blockade, a slowly developing decrease in presynaptic DA activity.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1176/ajp.139.3.297
发表时间：
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期刊：
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影响因子：
--
作者：
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通讯作者：
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DOI：
10.1176/ajp.141.2.296
发表时间：
1984
期刊：
The American journal of psychiatry
影响因子：
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作者：
BowersJr,MB
通讯作者：
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影响因子：
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作者：
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通讯作者：
Roth,RH