Simultaneous steering and imaging of magnetic particles using MRI toward delivery of therapeutics.
Simultaneous steering and imaging of magnetic particles using MRI toward delivery of therapeutics.
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DOI：
10.1038/srep33567
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发表时间：
2016-09-26
影响因子：
4.6
通讯作者：
Dupont PE
中科院分区：
文献类型：
--
作者：
Felfoul O;Becker AT;Fagogenis G;Dupont PE
磁共振导航（MRN）提供了将药物颗粒和细胞实时引导到全身靶点的可能性。在该技术中，MRI扫描仪的磁梯度执行磁标记治疗剂通过脉管系统并进入肿瘤的基于图像的转向。MRN当前技术的一个主要挑战是它们在用于粒子成像和推进的脉冲序列之间交替。由于在对粒子成像时不发生推进，这导致成像频率和推进力的显著降低。我们报告了一种新的方法，其中的成像序列的设计，同时图像和推进粒子。该序列提供了最大推进力和成像频率之间的折衷。在我们报告的示例中，该序列可以在27 Hz下成像，同时仍然产生由纯推进脉冲序列产生的95%的力。我们使用毫米级粒子在标准临床扫描仪上实现了我们的脉冲序列，并展示了多分支血管网络体模的高速（74 mm/s）导航。我们的研究表明，先前证明足以用于磁共振靶向（MRT）中的微米级治疗的纯推进的磁梯度幅度也足以用于这些粒子的实时转向。
Magnetic resonance navigation (MRN) offers the potential for real-time steering of drug particles and cells to targets throughout the body. In this technique, the magnetic gradients of an MRI scanner perform image-based steering of magnetically-labelled therapeutics through the vasculature and into tumours. A major challenge of current techniques for MRN is that they alternate between pulse sequences for particle imaging and propulsion. Since no propulsion occurs while imaging the particles, this results in a significant reduction in imaging frequency and propulsive force. We report a new approach in which an imaging sequence is designed to simultaneously image and propel particles. This sequence provides a tradeoff between maximum propulsive force and imaging frequency. In our reported example, the sequence can image at 27 Hz while still generating 95% of the force produced by a purely propulsive pulse sequence. We implemented our pulse sequence on a standard clinical scanner using millimetre-scale particles and demonstrated high-speed (74 mm/s) navigation of a multi-branched vascular network phantom. Our study suggests that the magnetic gradient magnitudes previously demonstrated to be sufficient for pure propulsion of micron-scale therapeutics in magnetic resonance targeting (MRT) could also be sufficient for real-time steering of these particles.
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影响因子：
14
作者：
Pouponneau, Pierre;Leroux, Jean-Christophe;Martel, Sylvain
通讯作者：
Martel, Sylvain
影响因子：
38.3
作者：
Dames, Petra;Gleich, Bernhard;Rudolph, Carsten
通讯作者：
Rudolph, Carsten
DOI：
10.1073/pnas.78.1.579
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
WIDDER, KJ;MORRIS, RM;SENYEI, AE
通讯作者：
SENYEI, AE
影响因子：
37.8
作者：
GABE, IT;GAULT, JH;BRAUNWAL.E
通讯作者：
BRAUNWAL.E
影响因子：
38.3
作者：
Namiki, Yoshihisa;Namiki, Tamami;Tada, Norio
通讯作者：
Tada, Norio