Erectile dysfunction and coronary artery calcification in incident dialysis patients.
Erectile dysfunction and coronary artery calcification in incident dialysis patients.
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DOI：
10.1007/s40620-021-00994-3
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发表时间：
2021-10
影响因子：
3.4
通讯作者：
Rosas SE
中科院分区：
文献类型：
--
作者：
Roy N;Rosas SE
勃起功能障碍在一般人群中与死亡率有关，在血液透析患者中很常见。我们的目的是确定血液透析患者勃起功能障碍、冠状动脉钙化和死亡率之间的关系。一组无冠状动脉疾病病史的成人透析患者在基线和至少12个月后接受了心电触发的多层螺旋CT(MSCT)扫描的冠状动脉钙化测量。勃起功能障碍采用15项有效的国际勃起功能指数(IIEF-15)问卷。勃起功能障碍在83%的患者中普遍存在，其中43%归类为重度勃起功能障碍，22.4%归类为中度勃起功能障碍，17.2%归类为轻度勃起功能障碍。有勃起功能障碍者冠状动脉钙化积分中位数为43.40.25~353.8，无勃起功能障碍者冠状动脉钙化积分为0(0~0)(p=0.007)。超过一半(55.6%)的勃起功能障碍患者经历了冠状动脉钙化的进展，而没有勃起功能障碍的患者中这一比例为14.3%(p=0.05)。平均随访5.2(1.3)年，死亡率为21%。勃起功能障碍患者的死亡率为23%，而无勃起功能障碍患者的死亡率为10%(p=0.4)。勃起功能障碍与死亡率无显著相关性[HR 1.2(1.3)，p=0.87]。勃起功能障碍在开始透析的人中很常见。它与冠状动脉钙化积分的增加显著相关，然而，它与无冠状动脉疾病病史的意外透析患者死亡率的增加无关。
Erectile dysfunction, which has been associated with mortality in the general population, is common in individuals on hemodialysis. Our aim was to determine the relationship between erectile dysfunction, coronary artery calcification and mortality in incident hemodialysis patients. A prospective cohort of incident adult dialysis patients with no history of coronary artery disease underwent coronary artery calcification measurement by ECG-triggered multi-slice computed tomography (MSCT) scan at baseline and at least 12 months later. Erectile dysfunction was determined using the 15-item validated International Index of Erectile Function (IIEF-15) questionnaire. Erectile dysfunction was prevalent in 83% of patients, with 43% classified as severe erectile dysfunction, 22.4% as moderate erectile dysfunction, and 17.2% as mild erectile dysfunction. The median (IQR) coronary artery calcification score was 43.4 (0.25–353.8) for those with erectile dysfunction and 0 (0–0) for those without erectile dysfunction (p = 0.007). More than half (55.6%) of the patients with erectile dysfunction experienced progression of coronary artery calcification compared to 14.3% of patients without erectile dysfunction (p = 0.05). Mortality was 21% during an average follow-up of 5.2 (1.3) years. Twenty-three percent of patients with erectile dysfunction died compared to 10% of people without erectile dysfunction (p = 0.4). Erectile dysfunction was not significantly associated with mortality [HR 1.2 (1.3), p = 0.87]. Erectile dysfunction is common in individuals who start dialysis. It is significantly associated with an increased coronary artery calcification score, however, it is not associated with increased mortality in incident dialysis patients with no history of coronary artery disease.
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影响因子：
2.4
作者：
Lee, John H.;Ngengwe, Raphael;O'Keefe, James H.
通讯作者：
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DOI：
10.1016/0735-1097(90)90282-t
发表时间：
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