Weight trajectories through infancy and childhood and risk of non-alcoholic fatty liver disease in adolescence: the ALSPAC study.
Weight trajectories through infancy and childhood and risk of non-alcoholic fatty liver disease in adolescence: the ALSPAC study.
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DOI：
10.1016/j.jhep.2014.04.018
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发表时间：
2014-09
影响因子：
25.7
通讯作者：
Lawlor, Debbie A.
中科院分区：
文献类型：
--
作者：
Anderson, Emma L.;Howe, Laura D.;Fraser, Abigail;Callaway, Mark P.;Sattar, Naveed;Day, Chris;Tilling, Kate;Lawlor, Debbie A.
肥胖是NAFLD的关键危险因素。很少有研究研究婴儿和儿童肥胖与随后的NAFLD风险之间的前瞻性关联。我们检查了从出生到10岁体重与身高的轨迹与青春期肝脏结果的关系，并评估了在结果评估时通过脂肪质量调节的关联程度。在雅芳父母和孩子纵向研究中，参与者的体重和身高轨迹是使用随机效应线性样条法模型估计的。对0-3个月、3个月-1岁、1-3岁、3-7岁和7-10岁出生体重(根据出生长度调整)和体重变化(根据长度/身高变化调整)与超声扫描(USS)测定的肝脏脂肪和硬度以及平均年龄17.8岁的血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)和γ-谷氨酰转移酶(GGT)进行线性和Logistic回归分析。在对平均年龄17.8岁的脂肪量进行调整后，评估了并发脂肪量的调节作用。出生体重与肝脏硬度呈正相关，与ALT和AST呈负相关。从出生到1岁的体重变化与预后无关。体重从1-3岁、3-7岁和7-10岁的变化与USS和基于血液的肝脏结果一致地呈正相关。对平均年龄为17.8岁的脂肪量进行调整后，这种关联朝着零的方向减弱，这表明关联在很大程度上是由同时存在的身体肥胖所调节的。体重与身高的比率在1岁到10岁之间的较大变化率一直与青春期的不良肝脏结果有关。这些联系在很大程度上是通过同时肥胖来调节的。
Adiposity is a key risk factor for NAFLD. Few studies have examined prospective associations of infant and childhood adiposity with subsequent NAFLD risk. We examined associations of weight-for-height trajectories from birth to age 10 with liver outcomes in adolescence, and assessed the extent to which associations are mediated through fat mass at the time of outcome assessment. Individual trajectories of weight and height were estimated for participants in the Avon Longitudinal Study of Parents and Children using random-effects linear-spline models. Associations of birthweight (adjusted for birth length) and weight change (adjusted for length/height change) from 0–3 months, 3 months–1 y, 1–3 y, 3–7 y, and 7–10 y with ultrasound scan (USS) determined liver fat and stiffness, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at mean age 17.8 y were assessed with linear and logistic regressions. Mediation by concurrent fat mass was assessed with adjustment for fat mass at mean age 17.8 y. Birth weight was positively associated with liver stiffness and negatively with ALT and AST. Weight change from birth to 1 y was not associated with outcomes. Weight change from 1–3 y, 3–7 y, and 7–10 y was consistently positively associated with USS and blood-based liver outcomes. Adjusting for fat mass at mean age 17.8 y attenuated associations toward the null, suggesting associations are largely mediated by concurrent body fatness. Greater rates of weight-for-height change between 1 y and 10 y are consistently associated with adverse liver outcomes in adolescence. These associations are largely mediated through concurrent fatness.
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影响因子：
29.4
作者：
Fraser, Abigail;Longnecker, Matthew P.;Lawlor, Debbie A.
通讯作者：
Lawlor, Debbie A.
影响因子：
3.2
作者：
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8.9
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Victora, CG
影响因子：
2.8
作者：
Fraser, Abigail;Ebrahim, Shah;Lawlor, Debbie A.
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Lawlor, Debbie A.
影响因子：
8.3
作者：
Alexander, BT
通讯作者：
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