Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue.
Natural Bioactive Compounds as Potential Browning Agents in White Adipose Tissue.
复制标题
天然生物活性化合物作为白色脂肪组织中潜在的布朗宁剂。
DOI：
10.1007/s11095-021-03027-7
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发表时间：
2021-04
影响因子：
3.7
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Choi Y;Yu L
超重和肥胖的流行是许多常见代谢疾病的基础。旨在减少能量摄入和/或刺激能量消耗的方法代表了控制体重增加的潜在策略。脂肪组织是一个主要的能量平衡器官。它可以分为白色脂肪组织（WAT）和棕色脂肪组织（BAT）。虽然WAT储存多余的代谢能量，但BAT通过适应性产热将其作为热量消散。WAT还通过提供产热燃料和通过在布朗宁后直接产生热量来参与产热。棕色WAT在形态和代谢上类似于BAT，被归类为米色脂肪。像BAT一样，米色脂肪可以产生热量。成年人有BAT样或米色脂肪。这种脂肪类型的招募和激活有可能增加能量消耗，从而对抗肥胖及其代谢并发症。鉴于此，能够诱导WAT布朗宁的试剂最近引起了生物医学、营养学和药学界的广泛关注。在这篇综述中，我们总结了天然生物活性化合物，已被证明可以促进动物和培养细胞中米色脂肪细胞的招募和激活。我们还讨论了每种化合物诱导脂肪布朗宁和代谢益处的潜在分子机制。
The epidemic of overweight and obesity underlies many common metabolic diseases. Approaches aimed to reduce energy intake and/or stimulate energy expenditure represent potential strategies to control weight gain. Adipose tissue is a major energy balancing organ. It can be classified as white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT stores excess metabolic energy, BAT dissipates it as heat via adaptive thermogenesis. WAT also participates in thermogenesis by providing thermogenic fuels and by directly generating heat after browning. Browned WAT resembles BAT morphologically and metabolically and is classified as beige fat. Like BAT, beige fat can produce heat. Human adults have BAT-like or beige fat. Recruitment and activation of this fat type have the potential to increase energy expenditure, thereby countering against obesity and its metabolic complications. Given this, agents capable of inducing WAT browning have recently attracted broad attention from biomedical, nutritional and pharmaceutical societies. In this review, we summarize natural bioactive compounds that have been shown to promote beige adipocyte recruitment and activation in animals and cultured cells. We also discuss potential molecular mechanisms for each compound to induce adipose browning and metabolic benefits.
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影响因子：
5.2
作者：
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