Residual strain and local strain distributions in the rabbit atherosclerotic aorta.
Residual strain and local strain distributions in the rabbit atherosclerotic aorta.
复制标题
兔动脉粥样硬化主动脉的残余应变和局部应变分布。
DOI：
10.1016/0021-9290(94)00179-8
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发表时间：
1995
影响因子：
2.4
通讯作者：
K. Ide
中科院分区：
文献类型：
--
作者：
T. Matsumoto;Kozaburo Hayashi;K. Ide
本文研究了动脉粥样硬化对兔胸主动脉壁残余应变的影响。动脉粥样硬化是通过喂饲胆固醇饲料或联合剥离主动脉内皮细胞和饮食喂养而诱导的。通过静压-内径试验测定生理状态下各大动脉的内径。从测量直径的位置获得环形试件。测量完空载直径后，径向切割环以测量其张开角。然后从打开的环状标本中获取组织切片。将截面划分为32个子节，并测量每个子节的局部尺寸。根据局部尺寸和在卸载和生理状态下的直径计算涉及开放构型的残余应变和体内应变。严重钙化发生前，张开角与内膜增生面积分数显著相关，与钙化区面积分数呈负相关。开放环标本的组织学观察显示，与增生性内膜相邻的中膜保持拉伸状态，而远离内膜的中膜松弛。局部应变分析表明，在无钙化的动脉粥样硬化性主动脉中，较厚的内膜出现较高的残余应变(压缩)，即较低的体内应变(拉伸)。这些结果表明：(A)内膜增生增加残余应变，从而减少在体内施加于内膜的应变；(B)钙化组织抑制邻近组织的变形。动脉内膜增生和钙化可能使动脉粥样硬化的应变场复杂化。
Effect of atherosclerosis on the residual strain in the arterial wall was studied in the rabbit thoracic aorta. Atherosclerosis was induced by feeding a cholesterol diet or by combining denudation of aortic endothelial cells with the diet feeding. Diameter of each aorta in the physiological state was determined from a static pressure-diameter test. A ring specimen was obtained from the position where the diameter was measured. After the measurement of its no-load diameters, the ring was cut radially to measure the opening angle. Histological section was then obtained from the opened-up ring specimen. The section was divided into 32 subsections and local dimensions were measured for each subsection. Residual and in vivo strains referring to the opened-up configuration were calculated from the local dimensions and the diameters in the unloaded and physiological states. The opening angle significantly correlated with the area fraction of intimal hyperplasia until severe calcification occurred, while it had a negative correlation with the area fraction of calcified region. Histological observation of opened-up ring specimens indicated that the media adjacent to hyperplastic intima remained stretched, while that away from the intima relaxed. Analysis of local strains showed that, in the atherosclerotic aorta without calcification, higher residual strain (compressive), i.e., lower in vivo strain (tensile), appears in the thicker intima. These results suggest that: (a) intimal hyperplasia increases residual strain and thus reduces the in vivo strain exerted in the intima and (b) calcified tissue restrains the deformation of adjacent tissues. The intimal hyperplasia and the calcification may complicate strain fields in the atherosclerotic aorta.
DOI：
10.1115/1.3168386
发表时间：
1989-11-01
影响因子：
1.7
作者：
LIU, SQ;FUNG, YC
通讯作者：
FUNG, YC
影响因子：
5.3
作者：
SCHMID, K;MCSHARRY, WO;BINETTE, JP
通讯作者：
BINETTE, JP
影响因子：
20.1
作者：
LOREE, HM;KAMM, RD;LEE, RT
通讯作者：
LEE, RT