CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.
CXCL5 Downregulation in Villous Tissue Is Correlated With Recurrent Spontaneous Abortion.
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绒毛组织中 CXCL5 下调与复发性自然流产相关
DOI：
10.3389/fimmu.2021.717483
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发表时间：
2021
影响因子：
7.3
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Zhang S;Ding J;Wang J;Yin T;Zhang Y;Yang J
复发性自然流产（RSA）影响着全世界5%的育龄妇女。滋养细胞侵袭不足是RSA发生的主要原因之一;然而，RSA的潜在分子机制尚未完全了解，迫切需要进一步解释。C-X-C基序趋化因子配体5（CXCL 5）被报道有助于癌细胞的侵袭，并且其异常表达与肿瘤病理的细胞过程相关。考虑到滋养层细胞和癌细胞之间的高度行为相似性，我们假设CXCL 5可能影响滋养层细胞的侵袭，其在绒毛组织中的表达水平可能与RSA相关。本研究首先检测了15例RSA患者和13例对照组胎盘绒毛组织中CXCL 5的表达，结果发现RSA患者绒毛组织中CXCL 5的表达水平明显低于对照组。进一步的体外实验表明，重组人CXCL 5可以增强滋养细胞的迁移、侵袭和上皮向间质转化（EMT）过程。我们还证实了CXCL 5通过PI 3 K/AKT/ERK 1/2信号通路对滋养层细胞发挥这些作用。总之，这些数据表明人绒毛组织中CXCL 5下调与RSA相关。此外，我们发现雌激素、孕激素、人绒毛膜促性腺激素和蜕膜基质细胞可以以细胞方式调节滋养层细胞CXCL 5和趋化因子受体2（CXCR 2）的表达。
Recurrent spontaneous abortion (RSA) affects 5% of childbearing-age women worldwide. Inadequate trophoblast invasion is one of the main reasons for the development of RSA; however, the underlying molecular mechanisms for RSA have not been fully understood, and further explanation is urgently needed. C-X-C motif chemokine ligand 5 (CXCL5) is reported to contribute to the invasion of cancer cells, and its aberrant expression is associated with the cellular process of tumor pathology. Considering the high behavioral similarity between trophoblast cells and cancer cells, we hypothesized that CXCL5 may influence trophoblast invasion, and its expression levels in villous tissue may be correlated with RSA. In this study, we firstly investigated the CXCL5 expression in placental villous tissues of 15 RSA patients and 13 control patients, and the results showed that CXCL5 levels were significantly lower in villous tissue from RSA patients than those of the controls. Further in vitro experiments presented that recombinant human CXCL5 can enhance trophoblast migration, invasion, and epithelial-to-mesenchymal transition (EMT) process. We also demonstrated that CXCL5 exerted these effects on trophoblast cells through PI3K/AKT/ERK1/2 signaling pathway. In conclusion, these data indicate that CXCL5 downregulation in human villous tissue is correlated with RSA. Additionally, we found that estrogen, progesterone, human chorionic gonadotropin, and decidual stromal cells can regulate CXCL5 and chemokine receptor 2 (CXCR2) expression of trophoblast in a cell manner.
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影响因子：
2.8
作者：
Huppertz B
通讯作者：
Huppertz B
影响因子：
3.6
作者：
Keelan, JA;Yang, J;Mitchell, MD
通讯作者：
Mitchell, MD
DOI：
10.1006/scel.1993.1022
发表时间：
1993-06-01
期刊：
Seminars in cell biology
影响因子：
--
作者：
Fisher, S J;Damsky, C H
通讯作者：
Damsky, C H
影响因子：
45.3
作者：
Cardwell, Chris R.;Hicks, Blanaid M.;Murray, Liam J.
通讯作者：
Murray, Liam J.
DOI：
10.3109/14767058.2015.1022864
发表时间：
2016-03
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Chaiworapongsa T;Romero R;Korzeniewski SJ;Chaemsaithong P;Hernandez-Andrade E;Segars JH;DeCherney AH;McCoy MC;Kim CJ;Yeo L;Hassan SS
通讯作者：
Hassan SS