The cullin protein family.
The cullin protein family.
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DOI：
10.1186/gb-2011-12-4-220
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发表时间：
2011
期刊：
影响因子：
12.3
通讯作者：
Pan ZQ
中科院分区：
文献类型：
--
作者：
Sarikas A;Hartmann T;Pan ZQ
Cullin蛋白是一种分子支架，在泛素参与的细胞蛋白质翻译后修饰中起着至关重要的作用。哺乳动物cullin蛋白家族包括八个成员（CUL 1至CUL 7和PARC），其特征在于cullin同源结构域。CUL 1至CUL 7组装多亚基Cullin-RING E3泛素连接酶（CRL）复合物，其是E3连接酶的最大家族，具有超过200个成员。虽然CUL 7和PARC仅存在于脊索动物中，但cullin蛋白家族的其他成员存在于果蝇、秀丽隐杆线虫、拟南芥和酵母中。cullin蛋白通常通过衔接蛋白将底物靶向单元和CRL中的RING指组件拴在一起。因此，cullin组织的CRL将底物定位在靠近RING结合的E2泛素缀合酶的位置，该酶催化泛素向底物的转移。此外，共轭cullin与泛素样分子Nedd 8调制激活相应的CRL复合物，可能通过构象调节cullin的羧基末端尾巴和CRL的环亚基之间的相互作用。在几种模式生物中的遗传学研究有助于解开与cullin蛋白及其各自的CRL相关的多种生理功能。CRL靶向许多底物，因此对一系列生物过程具有影响，包括细胞生长、发育、信号转导、转录控制、基因组完整性和肿瘤抑制。此外，CUL 7和CUL 4 B基因的突变与遗传性人类疾病有关。
Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin protein family comprises eight members (CUL1 to CUL7 and PARC), which are characterized by a cullin homology domain. CUL1 to CUL7 assemble multi-subunit Cullin-RING E3 ubiquitin ligase (CRL) complexes, the largest family of E3 ligases with more than 200 members. Although CUL7 and PARC are present only in chordates, other members of the cullin protein family are found in Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana and yeast. A cullin protein tethers both a substrate-targeting unit, often through an adaptor protein, and the RING finger component in a CRL. The cullin-organized CRL thus positions a substrate close to the RING-bound E2 ubiquitin-conjugating enzyme, which catalyzes the transfer of ubiquitin to the substrate. In addition, conjugation of cullins with the ubiquitin-like molecule Nedd8 modulates activation of the corresponding CRL complex, probably through conformational regulation of the interactions between cullin's carboxy-terminal tail and CRL's RING subunit. Genetic studies in several model organisms have helped to unravel a multitude of physiological functions associated with cullin proteins and their respective CRLs. CRLs target numerous substrates and thus have an impact on a range of biological processes, including cell growth, development, signal transduction, transcriptional control, genomic integrity and tumor suppression. Moreover, mutations in CUL7 and CUL4B genes have been linked to hereditary human diseases.
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影响因子：
64.5
作者：
Duda, David M.;Borg, Laura A.;Scott, Daniel C.;Hunt, Harold W.;Hammel, Michal;Schulman, Brenda A.
通讯作者：
Schulman, Brenda A.
影响因子：
46.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.0601638103
发表时间：
2006-05-16
影响因子：
11.1
作者：
Bullock, Alex N.;Debreczeni, Judit E.;Knapp, Stefan
通讯作者：
Knapp, Stefan
影响因子：
30.8
作者：
Dealy, MJ;Nguyen, KVT;Johnson, RS
通讯作者：
Johnson, RS
DOI：
10.1073/pnas.1733908100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Arai, T;Kasper, JS;DeCaprio, JA
通讯作者：
DeCaprio, JA