Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases.
Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases.
复制标题
糖尿病肾病新兴治疗策略的最新进展。
DOI：
10.3390/ijms231810882
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发表时间：
2022-09-17
影响因子：
5.6
通讯作者：
Zhang, Chun
中科院分区：
文献类型：
--
作者：
Huang, Wei;Chen, Yi-Yuan;Li, Zi-Qi;He, Fang-Fang;Zhang, Chun
糖尿病肾病(DKD)是全球终末期肾病最常见的病因之一。DKD的治疗与糖尿病患者的临床结局密切相关。传统的治疗策略侧重于控制主要危险因素，如血糖、血脂和血压。肾素-血管紧张素-醛固酮系统抑制剂是过去的主要治疗措施，但钠-葡萄糖共转运体2抑制剂、胰岛素类似物和内皮素-1受体拮抗剂的出现为DKD的治疗提供了更多的选择。同时，随着对DKD发病机制研究的深入，一些针对肾脏炎症、纤维化和氧化应激的新疗法逐渐进入临床应用。此外，最近发现的一些治疗靶点和信号通路，主要处于临床前和早期临床试验阶段，有望在未来为DKD患者提供好处。本文综述了DKD的传统治疗方法和新出现的治疗方法，展示了DKD治疗策略的最新进展。
Diabetic kidney disease (DKD) is one of the most common causes of end-stage renal disease worldwide. The treatment of DKD is strongly associated with clinical outcomes in patients with diabetes mellitus. Traditional therapeutic strategies focus on the control of major risk factors, such as blood glucose, blood lipids, and blood pressure. Renin–angiotensin–aldosterone system inhibitors have been the main therapeutic measures in the past, but the emergence of sodium–glucose cotransporter 2 inhibitors, incretin mimetics, and endothelin-1 receptor antagonists has provided more options for the management of DKD. Simultaneously, with advances in research on the pathogenesis of DKD, some new therapies targeting renal inflammation, fibrosis, and oxidative stress have gradually entered clinical application. In addition, some recently discovered therapeutic targets and signaling pathways, mainly in preclinical and early clinical trial stages, are expected to provide benefits for patients with DKD in the future. This review summarizes the traditional treatments and emerging management options for DKD, demonstrating recent advances in the therapeutic strategies for DKD.
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影响因子：
2.5
作者：
BRADWELL, AR;WRIGHT, AD;IMRAY, C
通讯作者：
IMRAY, C
维生素C封闭氧化应激会改善实验性糖尿病大鼠的蛋白尿和肾硬化。
影响因子：
2.4
作者：
Lee EY;Lee MY;Hong SW;Chung CH;Hong SY
通讯作者：
Hong SY
影响因子：
8.2
作者：
Brosius FC;Tuttle KR;Kretzler M
通讯作者：
Kretzler M
影响因子：
7.7
作者：
Chai, Zhonglin;Wu, Tieqiao;Cooper, Mark E.
通讯作者：
Cooper, Mark E.
DOI：
10.1152/ajprenal.00332.2011
发表时间：
2011-12-01
影响因子：
4.2
作者：
Awad, Alaa S.;Kinsey, Gilbert R.;Okusa, Mark D.
通讯作者：
Okusa, Mark D.