Effects of gestational low dose perfluorooctanoic acid on maternal and "anxiety-like" behavior in dams.
Effects of gestational low dose perfluorooctanoic acid on maternal and "anxiety-like" behavior in dams.
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DOI：
10.3389/ftox.2022.971970
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发表时间：
2022
影响因子：
--
通讯作者：
Sobolewski, Marissa
中科院分区：
文献类型：
--
作者：
Merrill, Alyssa K.;Conrad, Katherine;Marvin, Elena;Sobolewski, Marissa
关键词：
怀孕是一个独特的关键窗口，几乎无处不在地暴露于低浓度的内分泌干扰性化学品，如全氟烷基物质和多氟烷基物质(PFAS)。人类和动物研究表明，PFAS化合物扰乱了下丘脑-垂体-肾上腺轴的功能，并有一些证据表明“焦虑样”行为发生了改变，但人们对怀孕期间暴露于PFAS对母亲心理健康的潜在影响知之甚少。评估孕期接触PFAS对孕产妇健康的影响是至关重要的，因为大约十分之一的妇女经历产后抑郁，通常伴有更多的焦虑。为了弥补这一差距，从怀孕第0天到出生，水坝暴露在低剂量的全氟辛酸(PFOA)中，剂量为0.1 mg/kg。从出生后第5天至第9天观察母鼠的行为，并在断奶后用旷场自发运动行为和高架+迷宫测量“焦虑样”行为。在产仔数和后代性别方面没有观察到差异。孕期接触全氟辛烷磺酸改变了母亲的行为。尽管护理持续时间相似，但平卧位和侧卧位时，全氟辛酸盐水坝的护理时间较长，而后凸畸形的护理时间较少。尽管第一次接触的速度要快得多，但全氟辛烷磺酸水坝并没有更快地将幼崽送回巢中，这表明取回延迟缩短了。在断奶时，母鼠在高架+迷宫中表现出更多的“焦虑样”行为，关闭臂的平均持续时间显著延长，选择频率显著降低，关闭和开放臂的条目数量显著减少。全氟辛酸管理局的大坝在整个会议期间显示了流动活动的减少。孕期接触全氟辛烷磺酸改变了母亲的行为和水坝中的“焦虑样”行为。关注抑郁症相关行为的其他分析，如强迫游泳、快感缺乏和社会偏好，将进一步描述行为机制。对怀孕期间环境污染物暴露的影响的进一步研究应该调查联合暴露于其他危险因素，如压力，可能会增加行为毒性。了解怀孕期间环境污染物暴露如何影响母亲抑郁和/或“焦虑样”行为，对于妇女的公共卫生保护是必要的。
Pregnancy is a unique critical window with nearly ubiquitous exposure to low concentrations of endocrine disrupting chemicals, such as per- and poly-fluoroalkyl substances (PFAS). Human and animal research suggests that PFAS compounds disrupt hypothalamic-pituitary-adrenal axis function, with some evidence of altered “anxiety-like” behavior, but little is known about the potential effects on maternal mental health following exposures during pregnancy. Evaluating the consequences of gestational PFAS exposures on maternal health is essential, because approximately 1 in 10 women experience postpartum depression, often with increased anxiety. To address this gap, dams were exposed to a low dose, 0.1 mg/kg, of perfluorooctanoic acid (PFOA) from gestational day 0 to birth. Maternal behavior was then observed from postnatal days 5–9, and “anxiety-like” behavior was measured using open field spontaneous locomotor behavior and elevated plus maze following weaning. No difference was observed in the litter size or sex of offspring. Gestational PFOA exposure altered maternal behavior. Despite similar nursing durations, PFOA dams spent more time nursing in a flat posture and on their side, and less time in kyphosis. Despite significantly quicker first contact, PFOA dams did not return pups to the nest quicker, indicating reduced retrieval latency. At weaning, dams displayed increased “anxiety-like” behaviors in the elevated plus maze with a significantly higher mean duration in the closed arms and reduced choice frequency with significantly lower number of entries in the closed and open arms. PFOA dams showed reductions in ambulatory movement across the session. Pregnancy exposure to PFOA altered both maternal and “anxiety-like” behavior in dams. Additional assays focused on depression-associated behaviors, such as forced swim, anhedonia, and social preference, will further delineate behavioral mechanisms. Further research on the effects of environmental contaminant exposures during pregnancy should investigate how co-exposures to other risk factors, such as stress, may enhance behavioral toxicity. Understanding how environmental contaminant exposure during pregnancy effects maternal depression-associated, and/or “anxiety-like” behavior is necessary for the public health protection of women.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
11.4
作者：
Kalloo, Geetika;Wellenius, Gregory A.;McCandless, Lawrence;Calafat, Antonia M.;Sjodin, Andreas;Karagas, Margaret;Chen, Aimin;Yolton, Kimberly;Lanphear, Bruce P.;Braun, Joseph M.
通讯作者：
Braun, Joseph M.
DOI：
10.1016/j.reprotox.2009.02.012
发表时间：
2009-06
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Fenton SE;Reiner JL;Nakayama SF;Delinsky AD;Stanko JP;Hines EP;White SS;Lindstrom AB;Strynar MJ;Petropoulou SE
通讯作者：
Petropoulou SE
影响因子：
2.9
作者：
Boudalia, Sofiane;Berges, Raymond;Canivenc-Lavier, Marie-Chantal
通讯作者：
Canivenc-Lavier, Marie-Chantal
影响因子：
4.3
作者：
Derouiche L;Keller M;Martini M;Duittoz AH;Pillon D
通讯作者：
Pillon D