Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups.
Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups.
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DOI：
10.1016/j.reprotox.2009.02.012
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Petropoulou SE
中科院分区：
文献类型：
--
作者：
Fenton SE;Reiner JL;Nakayama SF;Delinsky AD;Stanko JP;Hines EP;White SS;Lindstrom AB;Strynar MJ;Petropoulou SE
先前在多次孕期暴露于全氟辛酸(PFOA)的小鼠身上的研究表明，许多剂量依赖的生长和发育效应，如果子代暴露在子宫中，似乎会恶化，从全氟辛酸暴露的水坝喂养。为了评价全氟辛酸在妊娠和哺乳母鼠及其子代体内的分布情况，在妊娠第17天，CD-1小鼠一次性给予0、0.1、1或5 mg/kg体重的全氟辛酸(n=25)。收集母鼠和仔鼠的体液和组织。幼鼠的血清全氟辛酸浓度显著高于它们各自的母鼠，并且它们的身体负担在出生后增加，直到至少出生后第8天，无论剂量如何。牛奶的分布：血清全氟辛酸因剂量和时间不同而不同，但通常超过0.20。这些数据表明，牛奶是小鼠暴露于全氟辛烷磺酸的重要途径，在这种化合物的风险评估建模设计中应予以考虑。
Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental effects which appeared to worsen if offspring exposed in utero nursed from PFOA-exposed dams. To evaluate the disposition of PFOA in the pregnant and lactating dam and her offspring, time-pregnant CD-1 mice received a single 0, 0.1, 1, or 5 mg PFOA/kg BW dose (n = 25/dose group) by gavage on gestation day 17. Maternal and pup fluids and tissues were collected over time. Pups exhibited significantly higher serum PFOA concentrations than their respective dams, and their body burden increased after birth until at least postnatal day 8, regardless of dose. The distribution of milk:serum PFOA varied by dose and time, but was typically in excess of 0.20. These data suggest that milk is a substantial PFOA exposure route in mice and should be considered in risk assessment modeling designs for this compound.
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影响因子：
10.4
作者：
Kärrman A;Ericson I;van Bavel B;Darnerud PO;Aune M;Glynn A;Lignell S;Lindström G
通讯作者：
Lindström G
影响因子：
3.4
作者：
Butenhoff, JL;Gaylor, DW;Zobel, LR
通讯作者：
Zobel, LR
影响因子：
5
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
5.5
作者：
HANWELL, A;LINZELL, JL
通讯作者：
LINZELL, JL
影响因子：
3.3
作者：
Reiner, Jessica L.;Nakayama, Shoji F.;Strynar, Mark J.
通讯作者：
Strynar, Mark J.