Synergistic pathogenesis of chicken infectious anemia virus and J subgroup of avian leukosis virus.
Synergistic pathogenesis of chicken infectious anemia virus and J subgroup of avian leukosis virus.
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鸡传染性贫血病毒与禽白血病病毒J亚群的协同发病机制
DOI：
10.1016/j.psj.2021.101468
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发表时间：
2021-11
期刊：
影响因子：
4.4
通讯作者：
Ye J
中科院分区：
文献类型：
--
作者：
Zhang J;Ma L;Li T;Li L;Kan Q;Yao X;Xie Q;Wan Z;Shao H;Qin A;Ye J
鸡传染性贫血病毒（CIAV）和J亚群禽白血病病毒（ALV-J）作为重要的免疫抑制病毒，给世界养禽业造成了巨大的经济损失。近年来，CIAV和ALV-J混合感染在我国鸡群中频繁发生。然而，CIAV和ALV-J的协同发病机制尚未得到充分研究。体外研究表明，CIAV能促进ALV-J在HD 11细胞中的复制，而ALV-J不能促进CIAV的复制。鸡感染试验表明CIAV和ALV-J具有协同作用，可引起感染鸡体重显著下降。虽然ALV-J对CIAV病毒脱落和组织载量没有影响，但CIAV确实显著增加了合并感染组中的ALV-J病毒血症、病毒脱落和组织载量。CIAV和ALV-J均能显著抑制H9 N2流感病毒和4型禽腺病毒（FAdV-4）的体液免疫。所有这些数据表明CIAV和ALV-J共感染的协同发病机制，并突出CIAV对ALV-J发病机制的积极作用。
As important immunosuppressive viruses, chicken infectious anemia virus (CIAV) and subgroup J avian leukosis virus (ALV-J) have caused huge economic losses to the poultry industry globally. Recently, the co-infection of CIAV and ALV-J frequently occurred in the domestic chicken flocks in China. However, the synergistic pathogenesis of CIAV and ALV-J has not been fully investigated. Here, a co-infection study was performed to further understand the potential synergistic pathogenesis of CIAV and ALV-J. In vitro study showed that CIAV could promote the replication of ALV-J in HD11 cells, but ALV-J could not increase the replication of CIAV. Chicken infection study showed both CIAV and ALV-J with synergistic effects caused significant body weight loss to the infected chickens. Although ALV-J had no effect on CIAV viral shedding and tissue load, CIAV did significantly increase ALV-J viremia, viral shedding and tissue load in the co-infection group. Moreover, both CIAV and ALV-J could significantly inhibit the humoral immunity to H9N2 influenza virus and serotype 4 fowl adenovirus (FAdV-4). All these data demonstrate the synergistic pathogenesis for the co-infection of CIAV and ALV-J, and highlight the positive effect of CIAV on the pathogenesis of ALV-J.
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影响因子：
3.1
作者：
Lee, MS;Chang, PC;Shieh, HK
通讯作者：
Shieh, HK
影响因子：
1.4
作者：
MCCONNELL, CDG;ADAIR, BM;MCNULTY, MS
通讯作者：
MCNULTY, MS
影响因子：
4.8
作者：
Wang Y;Song X;Gao H;Wang X;Hu Y;Gao Y;Qi X;Qin L;Lin H;Gao L;Yao S;Han C;Wang X;Chen H
通讯作者：
Chen H
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影响因子：
4.4
作者：
Feng M;Dai M;Cao W;Tan Y;Li Z;Shi M;Zhang X
通讯作者：
Zhang X
影响因子：
3.3
作者：
Erfan, Ahmed M.;Selim, Abdullah A.;Naguib, Mahmoud M.
通讯作者：
Naguib, Mahmoud M.